Antigen Information
General Information of This Antigen (ID: TAR0LXDND)
| Antigen Name | Lymphocyte antigen 6E (LY6E) |
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| Gene Name | LY6E |
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| Gene ID | ||||||
| Synonym | Retinoic acid-induced gene E protein;Stem cell antigen 2;Thymic shared antigen 1 |
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| Sequence |
MKIFLPVLLAALLGVERASSLMCFSCLNQKSNLYCLKPTICSDQDNYCVTVSASAGIGNL
VTFGHSLSKTCSPACPIPEGVNVGVASMGISCCQSFLCNFSAADGGLRASVTLLGAGLLL SLLPALLRFGP Click to Show/Hide
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| Function |
GPI-anchored cell surface protein that regulates T- lymphocytes proliferation, differentiation, and activation. Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation. Restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion. Also plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). Therefore, participates in the normal fusion of syncytiotrophoblast layer I (SynT- I) and in the proper morphogenesis of both fetal and maternal vasculatures within the placenta. May also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity.
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Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
| The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens | ||||
|---|---|---|---|---|
Anti-gD-LC-K149C
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
Alpha-gD-LC-K149C-10
[1]
|
seco-CBI-dimer |
Human Deoxyribonucleic acid (hDNA) |
Mc-peptidomimetic based linker 10 |
Anti-Ly6E antibody
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
M7437
|
Exatecan |
DNA topoisomerase 1 (TOP1) |
Undisclosed |
Anti-Ly6E-LC-K149C
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
Alpha-Ly6E-LC-K149C-11
[1]
|
seco-CBI-dimer |
Human Deoxyribonucleic acid (hDNA) |
Mal-PEG2 |
MLYE4489A
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
RG7841
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
Thio hu Anti-Ly6E 9B12.v12 LC K149C
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
WO2016205176A1 ADC-101
[2]
|
WO2016205176A1_ADC-101 payload |
Undisclosed |
WO2016205176A1_ADC-101 linker |
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WO2016205176A1 ADC-102
[2]
|
WO2016205176A1_ADC-102 payload |
Undisclosed |
WO2016205176A1_ADC-102 linker |
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WO2016205176A1 ADC-103
[2]
|
WO2016205176A1_ADC-103 payload |
Undisclosed |
WO2016205176A1_ADC-103 linker |
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WO2017059289A1 ADC-115
[3]
|
WO2017059289A1_ADC-115 payload |
Undisclosed |
WO2017059289A1_ADC-115 linker |
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WO2017059289A1 ADC-210
[3]
|
WO2017059289A1_ADC-210 payload |
Undisclosed |
WO2017059289A1_ADC-210 linker |
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WO2017214024A1 ADC-107
[4]
|
WO2017214024A1_ADC-107 payload |
Undisclosed |
WO2017214024A1_ADC-107 linker |
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WO2017214024A1 ADC-109
[4]
|
WO2017214024A1_ADC-109 payload |
Undisclosed |
WO2017214024A1_ADC-109 linker |
Thio hu Anti-Ly6E LC K149C
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
WO2017059289A1 ADC-212
[3]
|
WO2017059289A1_ADC-212 payload |
Undisclosed |
WO2017059289A1_ADC-212 linker |
Undisclosed
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
ZW327
[5]
|
Undisclosed |
Undisclosed |
Mc-Gly-Gly-Phe-Gly |
References