Payload Information

General Information of This Payload

Payload ID	PAY0RRIJY
Name	PBD dimer SG3552
Synonyms	PBD dimer SG3552 Click to Show/Hide
Target(s)	Human Deoxyribonucleic acid (hDNA)	Target Info

Each Antibody-drug Conjugate Related to This Payload

Full Information of The Activity Data of The ADC(s) Related to This Payload

Tb085-SG3376 [Investigative]

ADC Info

Revealed Based on the Cell Line Data

Click To Hide/Show 1 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC				[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	9.00 pM
Method Description	On day 3, groups of five mice were then treated with (1) 0.25 mg/kg Tb085-SG3376 or (2) 0.25 mg/kg NIP228-SG3376 or (3) PBS alone. Three uninfected mice were used as negative controls for the BLI.
In Vitro Model	.	T. brucei gambiense (T. b. brucei)	.

References

Ref 1	A single dose of antibody-drug conjugate cures a stage 1 model of African trypanosomiasis. PLoS Negl Trop Dis. 2019 May 23;13(5):e0007373. doi: 10.1371/journal.pntd.0007373. eCollection 2019 May.

If you find any error in data or bug in web service, please kindly report it to Dr. Shen et al.