Antibody Information

General Information of This Antibody

Antibody ID	ANI0NJUVO
Antibody Name	Anti-HpHbR mAb Tb085
Antibody Type	Monoclonal antibody (mAb)
Antibody Subtype	Humanized IgG
Antigen Name	Trypanosome haptoglobin-haemoglobin receptor (HpHbR)	Antigen Info

Each Antibody-drug Conjugate Related to This Antibody

Full Information of The Activity Data of The ADC(s) Related to This Antibody

Tb085-SG3376 [Investigative]

ADC Info

Revealed Based on the Cell Line Data

Click To Hide/Show 1 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC				[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	9.00 pM
Method Description	On day 3, groups of five mice were then treated with (1) 0.25 mg/kg Tb085-SG3376 or (2) 0.25 mg/kg NIP228-SG3376 or (3) PBS alone. Three uninfected mice were used as negative controls for the BLI.
In Vitro Model	.	T. brucei gambiense (T. b. brucei)	.

References

Ref 1	A single dose of antibody-drug conjugate cures a stage 1 model of African trypanosomiasis. PLoS Negl Trop Dis. 2019 May 23;13(5):e0007373. doi: 10.1371/journal.pntd.0007373. eCollection 2019 May.

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