Linker Information
General Information of This Linker
| Linker ID |
LIN0KRIDC
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| Linker Name |
Mal-Met-Lys
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C20H34N6O5S
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| Isosmiles |
CSCCC(NC(=O)C(N)CCCCN)C(=O)NCCNC(=O)CCN1C(=O)C=CC1=O
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| InChI |
InChI=1S/C20H34N6O5S/c1-32-13-8-15(25-19(30)14(22)4-2-3-9-21)20(31)24-11-10-23-16(27)7-12-26-17(28)5-6-18(26)29/h5-6,14-15H,2-4,7-13,21-22H2,1H3,(H,23,27)(H,24,31)(H,25,30)
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| InChIKey |
OHFJZRLLNNFUJZ-UHFFFAOYSA-N
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| Pharmaceutical Properties |
Molecule Weight
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470.596
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Polar area
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176.72
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Complexity
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32
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xlogp Value
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-1.7719
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Heavy Count
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32
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Rot Bonds
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16
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Hbond acc
|
8
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Hbond Donor
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5
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
1F6-Met-Lys-AF [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
3.00 ng/mL
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Positive CD70 expression (CD70+++/++) | ||
| Method Description |
IC50 values are the mean and SD of 21 independent experimental titrations, each performed at least in duplicate.
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| In Vitro Model | Hodgkin lymphoma | L-428 cells | CVCL_1361 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
4.00 ng/mL
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Positive CD70 expression (CD70+++/++) | ||
| Method Description |
IC50 values are the mean and SD of 21 independent experimental titrations, each performed at least in duplicate.
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| In Vitro Model | Clear cell renal cell carcinoma | Caki-1 cells | CVCL_0234 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
7.00 ng/mL
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Positive CD70 expression (CD70+++/++) | ||
| Method Description |
IC50 values are the mean and SD of 21 independent experimental titrations, each performed at least in duplicate.
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| In Vitro Model | Renal cell carcinoma | 786-O cells | CVCL_1051 | ||
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