Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0DTAIQ
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| ADC Name |
ISO-ADC
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| Synonyms |
ISO-ADC
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| Organization |
XADCERA BIOPHARMACEUTICAL (SUZHOU) CO., LTD.
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| Drug Status |
Investigative
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| Antibody Name |
undisclosed
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| Antigen Name |
Trophoblast glycoprotein (TPBG)
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Antigen Info | ||||
| Payload Name |
Monomethyl auristatin E
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Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
Undisclosed
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General Information of The Activity Data Related to This ADC
Discovered Using Patient-derived Xenograft Model
| Standard Type | Value | Units | Animal Model (No. of PDX) |
|---|---|---|---|
| Tumor Growth lnhibition value (TGl) |
-0.7
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%
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TPBG Patient-derived Xenograft Model
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Discovered Using Cell Line-derived Xenograft Model
| Standard Type | Value | Units | Cell Line | Disease Model |
|---|---|---|---|---|
| Tumor Growth lnhibition value (TGl) |
9.3
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%
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Undisclosed | Undisclosed |
Full List of Activity Data of This Antibody-drug Conjugate
Discovered Using Patient-derived Xenograft Model
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth lnhibition value (TGl) | -0.70% | Positive TPBG expression (TPBG+++/++) | ||
| Method Description |
The patient-derived tumor firagments (2mmx2mmx2mm,TPBG positive cells constituted 58.86% and MET positive cells constituted 24.08% of total cells) were engraftedin the right flank of B-NDG mice (Biocytogen Pharmaceuticals (Beijing) Co., Ltd., Cat#: B-CM-002). Treatment with 3mg/kg (QWƦ,i.v.) ADC after tumor volume about 200-300mm3. Determined tumor volume after the experiment, measured at day 28.
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| In Vivo Model | TPBG Patient-derived Xenograft Model | ||||
Discovered Using Cell Line-derived Xenograft Model
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth lnhibition value (TGl) |
9.30%
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| Method Description |
Cell line-derived xenograft models were established in B-NDG mice, by subcutaneous injection of 1x106 (NCI-H1975) tumor cells, and treatmen with 1.5mg/kg ADC (QWƦ,i.v.) after tumor volume about 200mm3. Determined tumor volume after the experiment, measured at day 28.
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| In Vivo Model | NCI-H1975 xenograft model | ||||