Antibody Information

General Information of This Antibody
Antibody ID
ANI0IJQEE
Antibody Name
Anti-CD4 mAb
Antibody Type
Monoclonal antibody (mAb)
Antibody Subtype
Humanized IgG
Antigen Name
T-cell surface glycoprotein CD4 (CD4)
  Antigen Info 
Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
CD4-Val-Cit-MMAE [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 3 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50)
18.00 nM
Positive CD4 expression (CD4 +++/++)
Method Description
Receptors (R2) as a function of ADC concentrations, upon incubation with the antibody and following additional 48 h.
In Vitro Model Adult T acute lymphoblastic leukemia MOLT-4 cells CVCL_0013
Experiment 2 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50)
22.00 nM
Positive CD4 expression (CD4 +++/++)
Method Description
Receptors (R1) as a function of ADC concentrations, upon incubation with the antibody and following additional 48 h.
In Vitro Model Adult T acute lymphoblastic leukemia MOLT-4 cells CVCL_0013
Experiment 3 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50)
40.00 nM
Positive CD4 expression (CD4 +++/++)
Method Description
Receptors (R4) as a function of ADC concentrations, upon incubation with the antibody and following additional 48 h.
In Vitro Model Adult T acute lymphoblastic leukemia MOLT-4 cells CVCL_0013
References
Ref 1 Chemical Artificial Internalizing Receptors for Primary T Cells. Adv Sci (Weinh). 2020 Jul 26;7(18):2001395. doi: 10.1002/advs.202001395. eCollection 2020 Sep.

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