Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0ADSSN
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| ADC Name |
AU2017363246B2 Conjugate83
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| Synonyms |
Conjugate83
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| Organization |
MERSANA THERAPEUTICS, INC.
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| Drug Status |
Investigative
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| Drug-to-Antibody Ratio |
15.7
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| Structure |
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| Antibody Name |
XMT-1535
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Antibody Info | ||||
| Antigen Name |
Sodium-dependent phosphate transport protein 2B (SLC34A2)
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Antigen Info | ||||
| Payload Name |
AU2017363246B2+Conjugate83+Payload
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Payload Info | ||||
| Linker Name |
AU2017363246B2+Conjugate83+Linker
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Linker Info | ||||
| Conjugate Type |
Random conjugation through reduced inter-chain cysteines.
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General Information of The ADMET Data Related to This ADC(2027 Update)
Absorption
| Standard Type | Value | Units | Description | Reference |
|---|---|---|---|---|
| Area Under the Concentration-Time Curve (AUC) | 402 | ug*hr/mL |
ADC with an AUC0 to 336 of 3- 402to718 ug·hr/mL.
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Distribution
| Standard Type | Value | Units | Description | Reference |
|---|---|---|---|---|
| Area Under the Concentration-Time Curve (AUC) | 402 | ug*hr/mL |
ADC with an AUC0 to 336 of 3- 402to718 ug·hr/mL.
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Metabolism
| Standard Type | Value | Units | Description | Reference |
|---|---|---|---|---|
| Area Under the Concentration-Time Curve (AUC) | 402 | ug*hr/mL |
ADC with an AUC0 to 336 of 3- 402to718 ug·hr/mL.
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Excretion
| Standard Type | Value | Units | Description | Reference |
|---|---|---|---|---|
| Elimination Half-Life (t1/2) | 114 | hr |
The terminal half-life is 114hr.
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| Area Under the Concentration-Time Curve (AUC) | 402 | ug*hr/mL |
ADC with an AUC0 to 336 of 3- 402to718 ug·hr/mL.
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General Information of The Activity Data Related to This ADC
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | 0.03 nmol/L | Negative her2 expression (her2-) | ||
| Method Description |
OVCAR3 cell line was plated at 5,000cell/well in black walled 96-well plate and allowed to adhere overnight. CellTiter-Glo reagent was added to the wells at room temperature and the luminescent signal was measured
after 10 min using a SpectraMax M5 plate reader (Molecular Devices). Dose response curves were generated using SoftMax Pro software. IC50 values were determined from four-parameter curve fitting
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| In Vitro Model | Ovarian carcinoma | OVCAR2 cells | CVCL_3941 | ||