Payload Information
General Information of This Payload
| Payload ID | PAY0FRPSB |
|||||
|---|---|---|---|---|---|---|
| Name | AU2017363246B2+Conjugate83+Payload |
|||||
| Synonyms |
AU2017363246B2+Conjugate83+Payload
Click to Show/Hide
|
|||||
Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
AU2017363246B2 Conjugate83 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.03 nmol/L
|
Negative her2 expression (her2-) | ||
| Method Description |
OVCAR3 cell line was plated at 5,000cell/well in black walled 96-well plate and allowed to adhere overnight. CellTiter-Glo reagent was added to the wells at room temperature and the luminescent signal was measured
after 10 min using a SpectraMax M5 plate reader (Molecular Devices). Dose response curves were generated using SoftMax Pro software. IC50 values were determined from four-parameter curve fitting
Click to Show/Hide
|
||||
| In Vitro Model | Ovarian carcinoma | OVCAR2 cells | CVCL_3941 | ||