Antigen Information

General Information of This Antigen
Antigen ID
TAR0YEKMX
Antigen Name
Transforming growth factor alpha (TGFA)
Gene Name
TGFA
Synonym
TGFA
Sequence
MVPSAGQLALFALGIVLAACQALENSTSPLSADPPVAAAVVSHFNDCPDSHTQFCFHGTC
RFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQAITALVVVSIVALAVLIITCVL
IHCCQVRKHCEWCRALICRHEKPSALLKGRTACCHSETVV

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Function
FUNCTION: TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.

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Uniprot Entry
TGFA_HUMAN
HGNC ID
HGNC:11765 ,
KEGG ID
hsa:7039 ,
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
40410803 16B10-DM1
Mertansine DM1
Undisclosed
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 [1]
 ADC Info 
40410803 16B10-Dxd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 [1]
 ADC Info 
40410803 16B10-MMAF
Monomethyl auristatin F
Microtubule (MT)
Mc-Val-Cit-PABC
 [1]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
40410803 5F1-DM1
Mertansine DM1
Undisclosed
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 [1]
 ADC Info 
40410803 5F1-Dxd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 [1]
 ADC Info 
40410803 5F1-MMAF
Monomethyl auristatin F
Microtubule (MT)
Mc-Val-Cit-PABC
 [1]
References
Ref 1 An antibody-drug conjugate targeting soluble and membrane-bound TGFα is effective against pancreatic tumors