Antibody Information

General Information of This Antibody

Antibody ID	ANI0HUNSM
Antibody Name	DAB4
Antibody Type	Monoclonal antibody (mAb)
Antibody Subtype	Murine IgG1
Antigen Name	Lupus-associated/Sjogren Syndrome-B (La/SSB)antigen	Antigen Info

Each Antibody-drug Conjugate Related to This Antibody

Full Information of The Activity Data of The ADC(s) Related to This Antibody

DAB4-DuoDM [Investigative]

ADC Info

Discovered Using Cell Line-derived Xenograft Model

Click To Hide/Show 1 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Tumor Growth Inhibition value (TGI)	≈ 71.40% (Day 8)	Positive La/SSB expression (La/SSB +++/++)
Method Description	A549 tumor-bearing mice were treated intraperitoneally with 150 mg/kg gemcitabine and 3 mg/kg cisplatin on Day 1. The day after chemotherapy, mice were treated with an intravenous injection of ADC.
In Vivo Model	A549 CDX model
In Vitro Model	Lung adenocarcinoma	A-549 cells		CVCL_0023

References

Ref 1	APOMAB Antibody-Drug Conjugates Targeting Dead Tumor Cells are Effective In Vivo. Mol Cancer Ther. 2019 Feb;18(2):335-345. doi: 10.1158/1535-7163.MCT-18-0842. Epub 2018 Nov 9.

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