Antigen Information

General Information of This Antigen (ID: TAR0TVUDL)
Antigen Name
Intercellular adhesion molecule 1 (ICAM1)
Gene Name
ICAM1
Gene ID
3383
Synonym
Major group rhinovirus receptor;CD54
Sequence
MAPSSPRPALPALLVLLGALFPGPGNAQTSVSPSKVILPRGGSVLVTCSTSCDQPKLLGI
ETPLPKKELLLPGNNRKVYELSNVQEDSQPMCYSNCPDGQSTAKTFLTVYWTPERVELAP
LPSWQPVGKNLTLRCQVEGGAPRANLTVVLLRGEKELKREPAVGEPAEVTTTVLVRRDHH
GANFSCRTELDLRPQGLELFENTSAPYQLQTFVLPATPPQLVSPRVLEVDTQGTVVCSLD
GLFPVSEAQVHLALGDQRLNPTVTYGNDSFSAKASVSVTAEDEGTQRLTCAVILGNQSQE
TLQTVTIYSFPAPNVILTKPEVSEGTEVTVKCEAHPRAKVTLNGVPAQPLGPRAQLLLKA
TPEDNGRSFSCSATLEVAGQLIHKNQTRELRVLYGPRLDERDCPGNWTWPENSQQTPMCQ
AWGNPLPELKCLKDGTFPLPIGESVTVTRDLEGTYLCRARSTQGEVTRKVTVNVLSPRYE
IVIITVVAAAVIMGTAGLSTYLYNRQRKIKKYRLQQAQKGTPMKPNTQATPP

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Family
CEA family
Function
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation.

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Uniprot Entry
ICAM1_HUMAN
HGNC ID
HGNC:5344
KEGG ID
hsa:3383
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
Anti-human ICAM-1 mAb (clone R6-5-D6)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ICAM-1-IR700 [1]
IRDye 700DX
Undisclosed
Undisclosed
 ADC Info 
Anti-ICAM1 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ICAM1-DM1 ADC [2]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
Chimeric ICAM1 Anti-ody (clone #R6.5)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
IC1-MMAE [3]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
IC1-MMAF [3]
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 ADC Info 
IC1-DM4 [3]
Mertansine DM4
Microtubule (MT)
Mal-EBE-Mal
 ADC Info 
IC1-DM1 [3]
Mertansine DM1
Microtubule (MT)
Mal-EBE-Mal
 ADC Info 
Chimeric ICAM1 Antibody (clone #R6.5)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
37146146 IC1-MMAE [4]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
37146146 IC1-MMAF [4]
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
 ADC Info 
37146146 IC1-DM1 [4]
Mertansine DM1
Microtubule (MT)
Mal-EBE-Mal
 ADC Info 
37146146 IC1-DM4 [4]
Mertansine DM4
Microtubule (MT)
Mal-EBE-Mal
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Enlimomab pegol [5]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ICAM-1-Dxd [6]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
37520726 I1-MMAE [7]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
37520726 I1-DXd [7]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
ICAM1-MMAE 3.92 [8]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ICAM1-MMAF 4.09 [8]
Monomethyl auristatin F
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ICAM1-DM1 3.96 [8]
Mertansine DM1
Microtubule (MT)
Mal-EBE-Mal
 ADC Info 
ICAM1-DM4 [8]
Mertansine DM4
Microtubule (MT)
Mal-EBE-Mal
 ADC Info 
IgG-DM1 [9]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
ICAM1-DM1 1-10 [9]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
IgG-Duo [9]
Seco-duocarmycin
Undisclosed
Mal-PEG4-VC-PAB-DMEA
 ADC Info 
ICAM1-Duo [9]
Seco-duocarmycin
Undisclosed
Mal-PEG4-VC-PAB-DMEA
 ADC Info 
IgG-MMAE 1-10 [9]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ICAM1-MMAE 1-10 [9]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
IgG-MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
6-Maleimidocaproic acid
 ADC Info 
ICAM1-MMAF 1-10 [9]
Monomethyl auristatin F
Microtubule (MT)
6-Maleimidocaproic acid
 ADC Info 
References
Ref 1 Intercellular adhesion molecule-1-targeted near-infrared photoimmunotherapy of triple-negative breast cancer. Cancer Sci. 2022 Sep;113(9):3180-3192.
Ref 2 A Rationally Designed ICAM1 Antibody Drug Conjugate for Pancreatic Cancer. Adv Sci (Weinh). 2020 Nov 3;7(24):2002852. doi: 10.1002/advs.202002852.
Ref 3 A rationally designed ICAM1 antibody drug conjugate eradicates late-stage and refractory triple-negative breast tumors in vivo. Sci Adv. 2023 May 5;9(18):eabq7866. doi: 10.1126/sciadv.abq7866. Epub 2023 May 5.
Ref 4 A rationally designed ICAM1 antibody drug conjugate eradicates late-stage and refractory triple-negative breast tumors in vivo
Ref 5 Introduction to basic information on ADC drug enlimomab pegol.
Ref 6 Reprogramming the Tumor Immune Microenvironment with ICAM-1-Targeted Antibody-Drug Conjugates and B7-H3-CD3 Bispecific Antibodies
Ref 7 ICAM1 antibody drug conjugates exert potent antitumor activity in papillary and anaplastic thyroid carcinoma
Ref 8 Intercellular adhesion molecule 1 (ICAM1) antibody drug conjugate and uses thereof
Ref 9 Intercellular adhesion molecule 1 (ICAM1) antibody-drug conjugates and uses thereof