Antigen Information

General Information of This Antigen
Antigen ID
TAR0TVUDL
Antigen Name
Intercellular adhesion molecule 1 (ICAM1)
Gene Name
ICAM1
Gene ID
3383
Synonym
Major group rhinovirus receptor;CD_antigen=CD54
Sequence
MAPSSPRPALPALLVLLGALFPGPGNAQTSVSPSKVILPRGGSVLVTCSTSCDQPKLLGI
ETPLPKKELLLPGNNRKVYELSNVQEDSQPMCYSNCPDGQSTAKTFLTVYWTPERVELAP
LPSWQPVGKNLTLRCQVEGGAPRANLTVVLLRGEKELKREPAVGEPAEVTTTVLVRRDHH
GANFSCRTELDLRPQGLELFENTSAPYQLQTFVLPATPPQLVSPRVLEVDTQGTVVCSLD
GLFPVSEAQVHLALGDQRLNPTVTYGNDSFSAKASVSVTAEDEGTQRLTCAVILGNQSQE
TLQTVTIYSFPAPNVILTKPEVSEGTEVTVKCEAHPRAKVTLNGVPAQPLGPRAQLLLKA
TPEDNGRSFSCSATLEVAGQLIHKNQTRELRVLYGPRLDERDCPGNWTWPENSQQTPMCQ
AWGNPLPELKCLKDGTFPLPIGESVTVTRDLEGTYLCRARSTQGEVTRKVTVNVLSPRYE
IVIITVVAAAVIMGTAGLSTYLYNRQRKIKKYRLQQAQKGTPMKPNTQATPP

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Family
CEA family
Function
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation.

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Uniprot Entry
ICAM1_HUMAN
HGNC ID
HGNC:5344
KEGG ID
hsa:3383
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
Anti-human ICAM-1 mAb (clone R6-5-D6)
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
ICAM-1-IR700
IRDye 700DX
Undisclosed
Undisclosed
 [1]
Anti-ICAM1 mAb
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
ICAM1-DM1 ADC
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 [2]
Chimeric ICAM1 Anti-ody (clone #R6.5)
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
IC1-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [3]
 ADC Info 
IC1-MMAF
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 [3]
 ADC Info 
IC1-DM4
Mertansine DM4
Microtubule (MT)
Mal-EBE-Mal
 [3]
 ADC Info 
IC1-DM1
Mertansine DM1
Microtubule (MT)
Mal-EBE-Mal
 [3]
Chimeric ICAM1 Antibody (clone #R6.5)
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
37146146 IC1-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [4]
 ADC Info 
37146146 IC1-MMAF
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
 [4]
 ADC Info 
37146146 IC1-DM1
Mertansine DM1
Microtubule (MT)
Mal-EBE-Mal
 [4]
 ADC Info 
37146146 IC1-DM4
Mertansine DM4
Microtubule (MT)
Mal-EBE-Mal
 [4]
Undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Enlimomab pegol
Undisclosed
Undisclosed
Undisclosed
 [5]
undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
ICAM-1-Dxd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 [6]
 ADC Info 
37520726 I1-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [7]
 ADC Info 
37520726 I1-DXd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 [7]
 ADC Info 
ICAM1-MMAE 3.92
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [8]
 ADC Info 
ICAM1-MMAF 4.09
Monomethyl auristatin F
Microtubule (MT)
Mc-Val-Cit-PABC
 [8]
 ADC Info 
ICAM1-DM1 3.96
Mertansine DM1
Microtubule (MT)
Mal-EBE-Mal
 [8]
 ADC Info 
ICAM1-DM4
Mertansine DM4
Microtubule (MT)
Mal-EBE-Mal
 [8]
 ADC Info 
IgG-DM1
Mertansine DM1
Microtubule (MT)
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 [9]
 ADC Info 
ICAM1-DM1 1-10
Mertansine DM1
Microtubule (MT)
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 [9]
 ADC Info 
IgG-Duo
Seco-duocarmycin
Undisclosed
Mal-PEG4-VC-PAB-DMEA
 [9]
 ADC Info 
ICAM1-Duo
Seco-duocarmycin
Undisclosed
Mal-PEG4-VC-PAB-DMEA
 [9]
 ADC Info 
IgG-MMAE 1-10
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [9]
 ADC Info 
ICAM1-MMAE 1-10
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [9]
 ADC Info 
IgG-MMAF
Monomethyl auristatin F
Microtubule (MT)
6-Maleimidocaproic acid
 [9]
 ADC Info 
ICAM1-MMAF 1-10
Monomethyl auristatin F
Microtubule (MT)
6-Maleimidocaproic acid
 [9]
References
Ref 1 Intercellular adhesion molecule-1-targeted near-infrared photoimmunotherapy of triple-negative breast cancer. Cancer Sci. 2022 Sep;113(9):3180-3192.
Ref 2 A Rationally Designed ICAM1 Antibody Drug Conjugate for Pancreatic Cancer. Adv Sci (Weinh). 2020 Nov 3;7(24):2002852. doi: 10.1002/advs.202002852.
Ref 3 A rationally designed ICAM1 antibody drug conjugate eradicates late-stage and refractory triple-negative breast tumors in vivo. Sci Adv. 2023 May 5;9(18):eabq7866. doi: 10.1126/sciadv.abq7866. Epub 2023 May 5.
Ref 4 A rationally designed ICAM1 antibody drug conjugate eradicates late-stage and refractory triple-negative breast tumors in vivo
Ref 5 Introduction to basic information on ADC drug enlimomab pegol.
Ref 6 Reprogramming the Tumor Immune Microenvironment with ICAM-1-Targeted Antibody-Drug Conjugates and B7-H3-CD3 Bispecific Antibodies
Ref 7 ICAM1 antibody drug conjugates exert potent antitumor activity in papillary and anaplastic thyroid carcinoma
Ref 8 Intercellular adhesion molecule 1 (ICAM1) antibody drug conjugate and uses thereof
Ref 9 Intercellular adhesion molecule 1 (ICAM1) antibody-drug conjugates and uses thereof