Antibody Information

General Information of This Antibody

Antibody ID	ANI0AQFCT
Antibody Name	Anti-human ICAM-1 mAb (clone R6-5-D6)
Antibody Type	Monoclonal antibody (mAb)
Antibody Subtype	Humanized IgG1-kappa
Antigen Name	Intercellular adhesion molecule 1 (ICAM1)	Antigen Info

Each Antibody-drug Conjugate Related to This Antibody

Full Information of The Activity Data of The ADC(s) Related to This Antibody

ICAM-1-IR700 [Investigative]

ADC Info

Discovered Using Cell Line-derived Xenograft Model

Click To Hide/Show 2 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Tumor Growth Inhibition value (TGI)	≈ 63.22% (Day 28)	High ICAM-1 expression (ICAM-1+++)
Method Description	Female homozygote athymic nude mice, 6-8 weeks old, MDA-MB-468-luc (4x10⁶) or MDA-MB-231 (1x10⁶) cells were inoculated into the right dorsum of mice. ICAM-1-IR700 (100 g) was injected 9 and 25days after cell inoculation, respectively (day 1). The mice were killed with CO₂ when the tumor volume reached 2000 mm³. Click to Show/Hide
In Vitro Model	Breast adenocarcinoma	MDA-MB-231 cells		CVCL_0062
Experiment 2 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Tumor Growth Inhibition value (TGI)	≈ 76.40% (Day 25)	High ICAM-1 expression (ICAM-1+++)
Method Description	Female homozygote athymic nude mice, 6-8 weeks old, MDA-MB-468-luc (4x10⁶) or MDA-MB-231 (1x10⁶) cells were inoculated into the right dorsum of mice. ICAM-1-IR700 (100 g) was injected 9 and 25days after cell inoculation, respectively (day 1). The mice were killed with CO₂ when the tumor volume reached 2000 mm³. Click to Show/Hide
In Vitro Model	Breast adenocarcinoma	MDA-MB-468 Luc cells		CVCL_0419

References

Ref 1	Intercellular adhesion molecule-1-targeted near-infrared photoimmunotherapy of triple-negative breast cancer. Cancer Sci. 2022 Sep;113(9):3180-3192.