Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)

ADC ID	DRG0PCAMO
ADC Name	ICAM-1-IR700
Synonyms	ICAM-1 IR700 Click to Show/Hide
Drug Status	Investigative
Indication	In total 1 Indication(s) Triple negative breast cancer [ICD11:2C60-2C65] Investigative
	3D MOL	2D MOL
Antibody Name	Anti-human ICAM-1 mAb (clone R6-5-D6)		Antibody Info
Antigen Name	Intercellular adhesion molecule 1 (ICAM1)		Antigen Info
Payload Name	IRDye 700DX		Payload Info
Linker Name	Undisclosed
Conjugate Type	Random conjugation through nucleophilic lysines.
Combination Type	Sarotalocan

General Information of The Activity Data Related to This ADC

Discovered Using Cell Line-derived Xenograft Model

Click To Hide/Show 2 Activity Data Related to This Level

Standard Type	Value	Units	Cell Line	Disease Model
Tumor Growth Inhibition value (TGI)	≈ 63.22	%	MDA-MB-231 cells	Breast adenocarcinoma
Tumor Growth Inhibition value (TGI)	≈ 76.4	%	MDA-MB-468 Luc cells	Breast adenocarcinoma

Full List of Activity Data of This Antibody-drug Conjugate

Discovered Using Cell Line-derived Xenograft Model

Click To Hide/Show 2 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Tumor Growth Inhibition value (TGI)	≈ 63.22% (Day 28)	High ICAM-1 expression (ICAM-1+++)
Method Description	Female homozygote athymic nude mice, 6-8 weeks old, MDA-MB-468-luc (4x10⁶) or MDA-MB-231 (1x10⁶) cells were inoculated into the right dorsum of mice. ICAM-1-IR700 (100 g) was injected 9 and 25days after cell inoculation, respectively (day 1). The mice were killed with CO₂ when the tumor volume reached 2000 mm³. Click to Show/Hide
In Vitro Model	Breast adenocarcinoma	MDA-MB-231 cells		CVCL_0062
Experiment 2 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Tumor Growth Inhibition value (TGI)	≈ 76.40% (Day 25)	High ICAM-1 expression (ICAM-1+++)
Method Description	Female homozygote athymic nude mice, 6-8 weeks old, MDA-MB-468-luc (4x10⁶) or MDA-MB-231 (1x10⁶) cells were inoculated into the right dorsum of mice. ICAM-1-IR700 (100 g) was injected 9 and 25days after cell inoculation, respectively (day 1). The mice were killed with CO₂ when the tumor volume reached 2000 mm³. Click to Show/Hide
In Vitro Model	Breast adenocarcinoma	MDA-MB-468 Luc cells		CVCL_0419

References

Ref 1	Intercellular adhesion molecule-1-targeted near-infrared photoimmunotherapy of triple-negative breast cancer. Cancer Sci. 2022 Sep;113(9):3180-3192.