General Information of This Antigen
Antigen ID
TAR0QMDMR
Antigen Name
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6)
Gene Name
CEACAM6
Gene ID
4680
Synonym
NCA
Sequence
MGPPSAPPCRLHVPWKEVLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLAHNLPQ
NRIGYSWYKGERVDGNSLIVGYVIGTQQATPGPAYSGRETIYPNASLLIQNVTQNDTGFY
TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPEVQNTTYLWWV
NGQSLPVSPRLQLSNGNMTLTLLSVKRNDAGSYECEIQNPASANRSDPVTLNVLYGPDVP
TISPSKANYRPGENLNLSCHAASNPPAQYSWFINGTFQQSTQELFIPNITVNNSGSYMCQ
AHNSATGLNRTTVTMITVSGSAPVLSAVATVGITIGVLARVALI

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Family
Immunoglobulin superfamily, CEA family
Function
FUNCTION: Cell surface glycoprotein that plays a role in cell adhesion and tumor progression (PubMed:10910050, PubMed:11590190, PubMed:1378450, PubMed:16204051, PubMed:2022629, PubMed:2803308, PubMed:8776764). Intercellular adhesion occurs in a calcium- and fibronectin-independent manner (PubMed:16204051, PubMed:2022629). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8 (PubMed:11590190, PubMed:16204051, PubMed:2022629, PubMed:2803308, PubMed:8776764). Heterophilic interaction with CEACAM8 occurs in activated neutrophils (PubMed:8776764). Plays a role in neutrophil adhesion to cytokine-activated endothelial cells (PubMed:1378450). Plays a role in cell migration and cell adhesion to endothelial cells (PubMed:16204051). {ECO:0000269|PubMed:10910050, ECO:0000269|PubMed:11590190, ECO:0000269|PubMed:1378450, ECO:0000269|PubMed:16204051, ECO:0000269|PubMed:2022629, ECO:0000269|PubMed:2803308, ECO:0000269|PubMed:8776764}.

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Uniprot Entry
CEAM6_HUMAN
HGNC ID
HGNC:1818 ,
KEGG ID
hsa:4680 ,
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
ADC Info ADC Name Payload Target Linker Ref
38467634 84-EBET
EBET-1055
Bromodomain and extra-terminal domain family (BET)
Undisclosed
[1]
39812376 84-EBET
EBET-1593
Undisclosed
Undisclosed
[2]
39812376 84-SN38
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
Undisclosed
[2]
39812376 84-Dxd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Undisclosed
[2]
39812376 84-MMAE
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
[2]
WO2024043319A1 1
WO2024043319A1 1 payload
Undisclosed
Undisclosed
[3]
WO2024043319A1 2
WO2024043319A1 5 payload
Undisclosed
Undisclosed
WO2024043319A1 3.9
WO2024043319A1 3.9 payload
Undisclosed
Undisclosed
[3]
WO2024043319A1 4
WO2024043319A1 4 payload
Undisclosed
WO2024043319A1 Linker 4
[3]
WO2024043319A1 5
WO2024043319A1 5 payload
Undisclosed
CN119630431A-ADC-81-LINKER
[3]
WO2024043319A1 6
WO2024043319A1 6 payload
Undisclosed
CN119630431A-ADC-81-LINKER
[3]
WO2024043319A1 7
CN119630431A ADC-51 payload
Undisclosed
Undisclosed
[3]
WO2024043319A1 8
CN119630431A ADC-51 payload
Undisclosed
Undisclosed
[3]
WO2024043319A1 9
CN119630431A ADC-51 payload
Undisclosed
Undisclosed
[3]
WO2024043319A1 10
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-21-LINKER
[3]
WO2024043319A1 11
CN119630431A ADC-51 payload
Undisclosed
Undisclosed
[3]
WO2024043319A1 12
CN119630431A ADC-51 payload
Undisclosed
Undisclosed
[3]
WO2024043319A1 13
WO2024043319A1 13 payload
Undisclosed
Undisclosed
[3]
WO2024043319A1 14
WO2024043319A1 14 payload
Undisclosed
Undisclosed
[3]
WO2024043319A1 15
WO2024043319A1 15 payload
Undisclosed
CN119630431A-ADC-26-LINKER
[3]
WO2024043319A1 16
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-27-LINKER
[3]
WO2024043319A1 17
CN119630431A ADC-51 payload
Undisclosed
WO2024043319A1 Linker 17
[3]
WO2024043319A1 18
WO2024043319A1 18 payload
Undisclosed
CN119630431A-ADC-29-LINKER
[3]
WO2024043319A1 19
CN119630431A ADC-51 payload
Undisclosed
Undisclosed
[3]
WO2024043319A1 20
WO2024043319A1 20 payload
Undisclosed
WO2024043319A1 Linker 20
[3]
WO2024043319A1 21
WO2024043319A1 21 payload
Undisclosed
CN119630431A-ADC-32-LINKER
[3]
WO2024043319A1 22
WO2024043319A1 22 payload
Undisclosed
CN119630431A-ADC-33-LINKER
[3]
WO2024043319A1 23
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-34-LINKER
[3]
WO2024043319A1 24
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-35-LINKER
[3]
WO2024043319A1 25
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-36-LINKER
[3]
WO2024043319A1 26
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-37-LINKER
[3]
WO2024043319A1 27
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-38-LINKER
[3]
WO2024043319A1 28
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-39-LINKER
[3]
WO2024043319A1 29
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-40-LINKER
[3]
WO2024043319A1 30
CN119630431A ADC-51 payload
Undisclosed
Undisclosed
[3]
WO2024043319A1 31
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-42-LINKER
[3]
WO2024043319A1 32
CN119630431A ADC-51 payload
Undisclosed
Undisclosed
[3]
WO2024043319A1 33
WO2024043319A1 33 payload
Undisclosed
Undisclosed
[3]
WO2024043319A1 34
CN119630431A ADC-51 payload
Undisclosed
Undisclosed
[3]
WO2024043319A1 35
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-46-LINKER
[3]
WO2024043319A1 36
CN119630431A ADC-51 payload
Undisclosed
Undisclosed
[3]
WO2024043319A1 37
CN119630431A ADC-51 payload
Undisclosed
Undisclosed
[3]
WO2024043319A1 38
CN119630431A ADC-51 payload
Undisclosed
Undisclosed
[3]
WO2024043319A1 39
CN119630431A ADC-51 payload
Undisclosed
Undisclosed
[3]
WO2024043319A1 40
CN119630431A ADC-51 payload
Undisclosed
Undisclosed
[3]
WO2024043319A1 41
WO2024043319A1 41 payload
Undisclosed
Undisclosed
[3]
WO2024043319A1 42
CN119630431A ADC-54 payload
Undisclosed
CN119630431A-ADC-53-LINKER
[3]
WO2024043319A1 43
WO2024043319A1 43 payload
Undisclosed
CN119630431A-ADC-54-LINKER
[3]
WO2024043319A1 44
WO2024043319A1 44 payload
Undisclosed
Undisclosed
[3]
WO2024043319A1 45
WO2024043319A1 45 payload
Undisclosed
Undisclosed
[3]
WO2024043319A1 46
Undisclosed
Undisclosed
Undisclosed
[3]
WO2024043319A1 47
WO2024043319A1 47 payload
Undisclosed
Undisclosed
[3]
WO2024043319A1 48
WO2024043319A1 48 payload
Undisclosed
Undisclosed
[3]
WO2024043319A1 49
Undisclosed
Undisclosed
Undisclosed
[3]
WO2024043319A1 50
WO2024043319A1 50 payload
Undisclosed
Undisclosed
[3]
WO2024043319A1 51
WO2024043319A1 51 payload
Undisclosed
Undisclosed
[3]
WO2024043319A1 52
WO2024043319A1 52 payload
Undisclosed
Undisclosed
[3]
WO2024043319A1 53
Undisclosed
Undisclosed
Undisclosed
[3]
WO2024043319A1 54
WO2024043319A1 54 payload
Undisclosed
Undisclosed
[3]
WO2024043319A1 55
WO2024043319A1 55 payload
Undisclosed
Undisclosed
[3]
WO2024043319A1 56
Undisclosed
Undisclosed
Undisclosed
[3]
WO2024043319A1 57
Undisclosed
Undisclosed
Undisclosed
[3]
WO2024043319A1 58
WO2024043319A1 58 payload
Undisclosed
Undisclosed
[3]
WO2024043319A1 59
WO2024043319A1 59 payload
Undisclosed
Undisclosed
[3]
WO2024043319A1 60
Undisclosed
Undisclosed
Undisclosed
[3]
WO2024043319A1 61
WO2024043319A1 61 payload
Undisclosed
Undisclosed
[3]
WO2024043319A1 62
WO2024043319A1 62 payload
Undisclosed
Undisclosed
[3]
WO2024043319A1 63
Undisclosed
Undisclosed
Undisclosed
[3]
WO2024043319A1 64
Undisclosed
Undisclosed
Undisclosed
[3]
WO2024043319A1 65
Undisclosed
Undisclosed
Undisclosed
[3]
WO2024043319A1 66
WO2024043319A1 66 payload
Undisclosed
Undisclosed
[3]
WO2024043319A1 67
Undisclosed
Undisclosed
Undisclosed
[3]
WO2024043319A1 68
WO2024043319A1 68 payload
Undisclosed
Undisclosed
[3]
WO2024043319A1 69
WO2024043319A1 69 payload
Undisclosed
Undisclosed
[3]
WO2024043319A1 70
WO2024043319A1 70 payload
Undisclosed
Undisclosed
[3]
WO2024043319A1 71
WO2024043319A1 71 payload
Undisclosed
Undisclosed
[3]
CN119630431A ADC-1
CN119630431A-ADC-1-PAYLOAD
Undisclosed
Undisclosed
[4]
CN119630431A ADC-2
CN119630431A ADC-51 payload
Undisclosed
Undisclosed
[4]
CN119630431A ADC-3
CN119630431A-ADC-1-PAYLOAD
Undisclosed
CN119630431A-ADC-3-LINKER
[4]
CN119630431A ADC-4
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-3-LINKER
[4]
CN119630431A ADC-5
CN119630431A-ADC-1-PAYLOAD
Undisclosed
CN119630431A-ADC-5-LINKER
[4]
CN119630431A ADC-12
CN119630431A-ADC-1-PAYLOAD
Undisclosed
CN119630431A-ADC-12-LINKER
[4]
CN119630431A ADC-13
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-12-LINKER
[4]
CN119630431A ADC-14
CN119630431A-ADC-14-PAYLOAD
Undisclosed
CN119630431A-ADC-12-LINKER
[4]
CN119630431A ADC-15
CN119630431A-ADC-15-PAYLOAD
Undisclosed
CN119630431A-ADC-12-LINKER
[4]
CN119630431A ADC-16
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-12-LINKER
[4]
CN119630431A ADC-17
CN119630431A-ADC-17-PAYLOAD
Undisclosed
CN119630431A-ADC-17-LINKER
[4]
CN119630431A ADC-18
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-18-LINKER
[4]
CN119630431A ADC-19
CN119630431A-ADC-17-PAYLOAD
Undisclosed
CN119630431A-ADC-19-LINKER
[4]
CN119630431A ADC-20
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-20-LINKER
[4]
CN119630431A ADC-21
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-21-LINKER
[4]
CN119630431A ADC-22
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-22-LINKER
[4]
CN119630431A ADC-23
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-23-LINKER
[4]
CN119630431A ADC-24
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-24-LINKER
[4]
CN119630431A ADC-25
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-24-LINKER
[4]
CN119630431A ADC-26
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-26-LINKER
[4]
CN119630431A ADC-27
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-27-LINKER
[4]
CN119630431A ADC-28
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-28-LINKER
[4]
CN119630431A ADC-29
CN119630431A-ADC-29-PAYLOAD
Undisclosed
CN119630431A-ADC-29-LINKER
[4]
CN119630431A ADC-30
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-30-LINKER
[4]
CN119630431A ADC-31
CN119630431A ADC-51 payload
Undisclosed
WO2024043319A1 Linker 20
[4]
CN119630431A ADC-32
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-32-LINKER
[4]
CN119630431A ADC-33
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-33-LINKER
[4]
CN119630431A ADC-34
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-34-LINKER
[4]
CN119630431A ADC-35
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-35-LINKER
[4]
CN119630431A ADC-36
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-36-LINKER
[4]
CN119630431A ADC-37
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-37-LINKER
[4]
CN119630431A ADC-38
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-38-LINKER
[4]
CN119630431A ADC-39
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-39-LINKER
[4]
CN119630431A ADC-40
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-40-LINKER
[4]
CN119630431A ADC-41
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-41-LINKER
[4]
CN119630431A ADC-42
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-42-LINKER
[4]
CN119630431A ADC-43
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-43-LINKER
[4]
CN119630431A ADC-44
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-44-LINKER
[4]
CN119630431A ADC-45
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-41-LINKER
[4]
CN119630431A ADC-46
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-46-LINKER
[4]
CN119630431A ADC-47
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-47-LINKER
[4]
CN119630431A ADC-48
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-48-LINKER
[4]
CN119630431A ADC-49
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-49-LINKER
[4]
CN119630431A ADC-50
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-50-LINKER
[4]
CN119630431A ADC-51
CN119630431A ADC-51 payload
Undisclosed
CN119630431A-ADC-51-LINKER
[4]
CN119630431A ADC-52
CN119630431A-ADC-52-PAYLOAD
Undisclosed
CN119630431A-ADC-52-LINKER
[4]
CN119630431A ADC-53
CN119630431A ADC-54 payload
Undisclosed
CN119630431A-ADC-53-LINKER
[4]
CN119630431A ADC-54
CN119630431A ADC-54 payload
Undisclosed
CN119630431A-ADC-54-LINKER
[4]
CN119630431A ADC-55
CN119630431A-ADC-55-PAYLOAD
Undisclosed
CN119630431A-ADC-55-LINKER
[4]
CN119630431A ADC-56
CN119630431A-ADC-56-PAYLOAD
Undisclosed
CN119630431A-ADC-56-LINKER
[4]
CN119630431A ADC-57
CN119630431A-ADC-58-PAYLOAD
Undisclosed
CN119630431A-ADC-56-LINKER
[4]
CN119630431A ADC-58
undisclosed
Undisclosed
CN119630431A-ADC-58-LINKER
[4]
CN119630431A ADC-59
CN119630431A-ADC-58-PAYLOAD
Undisclosed
CN119630431A-ADC-58-LINKER
[4]
CN119630431A ADC-60
CN119630431A-ADC-60-PAYLOAD
Undisclosed
CN119630431A-ADC-32-LINKER
[4]
CN119630431A ADC-61
CN119630431A-ADC-60-PAYLOAD
Undisclosed
CN119630431A-ADC-61-LINKER
[4]
CN119630431A ADC-62
CN119630431A-ADC-62-PAYLOAD
Undisclosed
CN119630431A-ADC-58-LINKER
[4]
CN119630431A ADC-63
CN119630431A-ADC-63-PAYLOAD
Undisclosed
CN119630431A-ADC-58-LINKER
[4]
CN119630431A ADC-64
CN119630431A-ADC-64-PAYLOAD
Undisclosed
CN119630431A-ADC-64-LINKER
[4]
CN119630431A ADC-65
CN119630431A-ADC-65-PAYLOAD
Undisclosed
CN119630431A-ADC-65-LINKER
[4]
CN119630431A ADC-66
CN119630431A-ADC-65-PAYLOAD
Undisclosed
CN119630431A-ADC-66-LINKER
[4]
CN119630431A ADC-67
CN119630431A-ADC-67-PAYLOAD
Undisclosed
CN119630431A-ADC-67-LINKER
[4]
CN119630431A ADC-68
CN119630431A-ADC-67-PAYLOAD
Undisclosed
CN119630431A-ADC-33-LINKER
[4]
CN119630431A ADC-69
CN119630431A-ADC-69-PAYLOAD
Undisclosed
CN119630431A-ADC-66-LINKER
[4]
CN119630431A ADC-70
CN119630431A-ADC-70-PAYLOAD
Undisclosed
CN119630431A-ADC-70-LINKER
[4]
CN119630431A ADC-71
CN119630431A-ADC-71-PAYLOAD
Undisclosed
CN119630431A-ADC-33-LINKER
[4]
CN119630431A ADC-72
CN119630431A-ADC-72-PAYLOAD
Undisclosed
CN119630431A-ADC-70-LINKER
[4]
CN119630431A ADC-73
CN119630431A-ADC-73-PAYLOAD
Undisclosed
CN119630431A-ADC-33-LINKER
[4]
CN119630431A ADC-74
CN119630431A-ADC-74-PAYLOAD
Undisclosed
CN119630431A-ADC-74-LINKER
[4]
CN119630431A ADC-75
CN119630431A-ADC-75-PAYLOAD
Undisclosed
CN119630431A-ADC-75-LINKER
[4]
CN119630431A ADC-76
CN119630431A-ADC-76-PAYLOAD
Undisclosed
CN119630431A-ADC-76-LINKER
[4]
CN119630431A ADC-77
CN119630431A-ADC-77-PAYLOAD
Undisclosed
CN119630431A-ADC-77-LINKER
[4]
CN119630431A ADC-78
CN119630431A-ADC-78-PAYLOAD
Undisclosed
CN119630431A-ADC-78-LINKER
[4]
CN119630431A ADC-79
CN119630431A-ADC-79-PAYLOAD
Undisclosed
CN119630431A-ADC-79-LINKER
[4]
CN119630431A ADC-80
CN119630431A-ADC-80-PAYLOAD
Undisclosed
CN119630431A-ADC-80-LINKER
[4]
CN119630431A ADC-81
CN119630431A-ADC-80-PAYLOAD
Undisclosed
CN119630431A-ADC-81-LINKER
[4]
CEACAM6 HCAb
ADC Info ADC Name Payload Target Linker Ref
HCAb-ADC
Undisclosed
Undisclosed
Undisclosed
[5]
undisclosed
ADC Info ADC Name Payload Target Linker Ref
CD66c-DXd
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
[6]
References
Ref 1 Delivery of a BET protein degrader via a CEACAM6-targeted antibody-drug conjugate inhibits tumour growth in pancreatic cancer models
Ref 2 Broad-Spectrum Efficacy of CEACAM6-Targeted Antibody-Drug Conjugate with BET Protein Degrader in Colorectal, Lung, and Breast Cancer Mouse Models
Ref 3 Antibody-drug complexes
Ref 4 Antibody-drug conjugates
Ref 5 A novel anti-CEACAM6 heavy-chain antibody-drug conjugate for gastrointestinal cancer therapy
Ref 6 Identification of CD66c as a potential target in gastroesophageal junction cancer for antibody-drug conjugate development