Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)
ADC ID
DRG0ROJDC
ADC Name
WO2024043319A1 13
Synonyms
WO2024043319A1 WO2024043319A1 13
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Organization
EISAI R&D MANAGEMENT CO., LTD.
Drug Status
Investigative
Drug-to-Antibody Ratio
2.7
Structure
Antibody Name
#84.7
  Antibody Info 
Antigen Name
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6)
  Antigen Info 
Payload Name
WO2024043319A1 13 payload
  Payload Info 
Linker Name
Undisclosed
General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Standard Type Value Units Cell Line Disease Model
Half Maximal inhibitory Concentration (lC50) 
0.043
nM
CVCL_0152
Pancreatic ductal adenocarcinoma
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50) 0.043 nM Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++)
Method Description
In vitro cytotoxicity of ADCs in AsPC-1 cells.
In Vitro Model Pancreatic ductal adenocarcinoma AsPC-1 cells CVCL_0152
References
Ref 1 Antibody-drug complexes