Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)
ADC ID
DRG0SFRRO
ADC Name
WO2024043319A1 12
Synonyms
WO2024043319A1 WO2024043319A1 12
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Organization
EISAI R&D MANAGEMENT CO., LTD.
Drug Status
Investigative
Drug-to-Antibody Ratio
3.8
Structure
Antibody Name
#84.7
  Antibody Info 
Antigen Name
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6)
  Antigen Info 
Payload Name
CN119630431A ADC-51 payload
  Payload Info 
Linker Name
Undisclosed
General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Standard Type Value Units Cell Line Disease Model
Half Maximal inhibitory Concentration (lC50) 
0.038
nM
CVCL_0152
Pancreatic ductal adenocarcinoma
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50) 0.038 nM Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++)
Method Description
In vitro cytotoxicity of ADCs in AsPC-1 cells.
In Vitro Model Pancreatic ductal adenocarcinoma AsPC-1 cells CVCL_0152
References
Ref 1 Antibody-drug complexes