Antigen Information

General Information of This Antigen
Antigen ID
TAR0JMGXV
Antigen Name
Membrane cofactor protein (CD46)
Gene Name
CD46
Gene ID
4179
Synonym
MCP; MIC10; TLX;Trophoblast leukocyte common antigen;CD_antigen=CD46
Sequence
MEPPGRRECPFPSWRFPGLLLAAMVLLLYSFSDACEEPPTFEAMELIGKPKPYYEIGERV
DYKCKKGYFYIPPLATHTICDRNHTWLPVSDDACYRETCPYIRDPLNGQAVPANGTYEFG
YQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKHTFSEVEV
FEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGKQIS
GFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLKVLPPSSTKPPALSHS
VSTSSTTKSPASSASGPRPTYKPPVSNYPGYPKPEEGILDSLDVWVIAVIVIAIVVGVAV
ICVVPYRYLQRRKKKGTYLTDETHREVKFTSL

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Function
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.

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Uniprot Entry
MCP_HUMAN
HGNC ID
HGNC:6953
KEGG ID
hsa:4179
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
Anti-CD46 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
T2LD6 [1]
N-methyl-uncialamycin
Human Deoxyribonucleic acid (hDNA)
Mal-Val-Cit-gucuronide-PEG8-PABC
 ADC Info 
T2LD5 [1]
N-methyl-uncialamycin
Human Deoxyribonucleic acid (hDNA)
Mal-Val-Cit-glucuronide-PABC
 ADC Info 
T2LD4 [1]
N-methyl-uncialamycin
Human Deoxyribonucleic acid (hDNA)
Mal-glucuronidase cleavable linker
 ADC Info 
T2LD3 [1]
N-methyl-uncialamycin
Human Deoxyribonucleic acid (hDNA)
Mal-PEG8
 ADC Info 
T2LD2 [1]
N-methyl-uncialamycin
Human Deoxyribonucleic acid (hDNA)
Mal-acetic acid
 ADC Info 
T2LD1 [1]
N-methyl-uncialamycin
Human Deoxyribonucleic acid (hDNA)
Mal-Val-Cit-PABC
 ADC Info 
HCD46-19 [2]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Hydrophilic cleavable linker 19
 ADC Info 
HCD46-25 [2]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Alternative linker without basic amines linker 25
 ADC Info 
HCD46-26 [2]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Maleimide based noncleavable linker 26
 ADC Info 
HCD46-29 [2]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
PNU-thiazole cleavable linker 29
 ADC Info 
Anti-CD46 mAb 23AG2
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CD46-ADC [3]
Monomethyl auristatin F
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
FOR46
MMAE
Microtubule (MT)
A cleavable linker
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-CD46 antibody-drug conjugate [4]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Anti-CD46-antibody drug conjugate (AbbVie) [5]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD46 CAB-ADC [6]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CD46-ADC [7]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
References
Ref 1 Uncialamycin-based antibody-drug conjugates: Unique enediyne ADCs exhibiting bystander killing effect. Proc Natl Acad Sci U S A. 2021 Jun 22;118(25):e2107042118. doi: 10.1073/pnas.2107042118.
Ref 2 Evaluation of PNU-159682 antibody drug conjugates (ADCs). Bioorg Med Chem Lett. 2020 Dec 15;30(24):127640. doi: 10.1016/j.bmcl.2020.127640. Epub 2020 Oct 28.
Ref 3 Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells. J Clin Invest. 2016 Dec 1;126(12):4640-4653. doi: 10.1172/JCI85856. Epub 2016 Nov 14.
Ref 4 Introduction to basic information on anti-CD46 antibody-drug conjugate(University of California San Francisco/Washington University in St Louis).
Ref 5 Introduction to basic information on anti-CD46- antibody drug conjugates(AbbVie).
Ref 6 Conditionally active biologics (CAB): A novel class of molecules targeting solid tumors. Cancer Res (2020) 80 (16_Supplement): 4560.
Ref 7 CD46-ADC Reduces the Engraftment of Multiple Myeloma Patient-Derived Xenografts