Antibody Information
General Information of This Antibody
| Antibody ID | ANI0QNBSC |
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| Antibody Name | Anti-CD46 fully human Anti-ody |
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| Organization | University of California San Diego; Fortis Therapeutics, Inc. |
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| Synonyms |
Anti-CD46 fully human Anti-ody
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| Antibody Type | Monoclonal antibody (mAb) |
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| Antigen Name | Membrane cofactor protein (CD46) |
Antigen Info | ||||
Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
FOR-46 [Phase 2]
Identified from the Human Clinical Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Partial Response (PR) |
22.20%
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| Patients Enrolled |
Metastatic castration-resistant prostate cancer (CRPC).
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| Administration Dosage |
Intravenous FOR46 on day 1 of every 21-day cycle. Dose levels ranged from 0.10 mg/kg. the starting dose level, to 3.00 mg/kg. The trial established 2.70 mg/kg to be the maximum tolerated dose (MTD) and the recommended phase 2 dose (RP2D) of the agent.
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| Related Clinical Trial | |||||
| NCT Number | NCT03575819 | Clinical Status | Phase 1 | ||
| Clinical Description |
A phase 1 study of FOR46 administered every 21 days in patients with metastatic castration-resistant prostate cancer (mCRPC).
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| Primary Endpoint |
MtD and phase 1b dose=2.70 mg/kg.
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| Other Endpoint |
18 pts had measurable lesions; 8 of 18 (44.44%) had tumor regression, with 4 (22.22%) confirmed partial responses (PR). The median duration of response is > 14 wks (range 9 -31+ weeks).
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| Experiment 2 Reporting the Activity Date of This ADC | [2] | ||||
| Related Clinical Trial | |||||
| NCT Number | NCT05011188 | Clinical Status | Phase 1/2 | ||
| Clinical Description |
A phase 1b/2 study of FOR46 in combination with enzalutamide in patients with metastatic castration resistant prostate cancer.
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| Experiment 3 Reporting the Activity Date of This ADC | [3] | ||||
| Related Clinical Trial | |||||
| NCT Number | NCT03650491 | Clinical Status | Phase 1 | ||
| Clinical Description |
A phase 1 study of FOR46 administered every 21 days in patients with relapsed or refractory multiple myeloma (RRMM).
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References