Target Information

General Information of This Target (ID: PATR0IMSYD)
Target Name
Ribosome (RB)
Function
Ribosome (RB) are macromolecular machines, found within all cells, that perform biological protein synthesis (mRNA translation). Ribosomes link amino acids together in the order specified by the codons of messenger RNA (mRNA) molecules to form polypeptide chains. Ribosomes consist of two major components: the small and large ribosomal subunits. Each subunit consists of one or more ribosomal RNA (rRNA) molecules and many ribosomal proteins (RPs or r-proteins).

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Full List of The ADC Related to This Target
Phase 1 (discontinued)
Click To Hide/Show 1 ADC Related to This Stage
ADC Name Antibody Antigen Payload Linker ADC Info
MT-5111
Undisclosed
Receptor tyrosine-protein kinase erbB-2 (HER2)
Shiga toxin B subunit (StxB)
Undisclosed
ADC Info
Investigative
Click To Hide/Show 11 ADC Related to This Stage
ADC Name Antibody Antigen Payload Linker ADC Info
Trastuzumab-Gelonin [1]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Gelonin
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
ADC Info
1B-3R ADC [2]
Undisclosed
Lactosylceramide 4-alpha-galactosyltransferase (A4GALT)
Shiga toxin B subunit (StxB)
Undisclosed
ADC Info
Cetuximab-Puromycin [3]
Cetuximab
Epidermal growth factor receptor (EGFR)
Puromycin
Succinimidyl acetylthiopropionate (SATP)
ADC Info
OMTX-503 [4]
OMTX003
Endoglin (ENG)
Nigrin b
Succynimidyloxycarbonyl-alpha-methyl-alpha-(2-pyridyl-dithio) toluene (SMPT)
ADC Info
TAK-169 [5]
Undisclosed
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38)
Ribosome inactivating SLTA
Undisclosed
ADC Info
Monoclonal antibody ZME-018-gelonin conjugate [6]
Murine mAb ZME-018
Human gp240 antigen
Gelonin
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
ADC Info
Monoclonal antibody LYM-1-gelonin conjugate [7]
LYM-1
HLA class II histocompatibility antigen, DR alpha chain (HLA-DRA)
Gelonin
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
ADC Info
Anti-B7-2-gelonin immunotoxin [8]
Anti-CD86 mAb 1G10
T-lymphocyte activation antigen CD86 (CD86)
Gelonin
Undisclosed
ADC Info
Monoclonal antibody TP3-PAP conjugate [9]
TP-3 murine mAb
TNF receptor superfamily member 1B (TNFRSF1B)
Pokeweed antiviral protein (PAP)
Undisclosed
ADC Info
BAT123-PAP-S [10]
BAT 123
Envelope glycoprotein gp160 (env)
Pokeweed antiviral protein
Undisclosed
ADC Info
Telimomab aritox [11]
Anti-CD5 mAb T101
T-cell surface glycoprotein CD5 (CD5)
Ricin A-chain
Undisclosed
ADC Info
Investigative(Terminated)
Click To Hide/Show 1 ADC Related to This Stage
ADC Name Antibody Antigen Payload Linker ADC Info
Monoclonal antibody B4G7-gelonin conjugate [12]
Anti-EGF murine mAb B4G7
Pro-epidermal growth factor (EGF)
Gelonin
Undisclosed
ADC Info
References
Ref 1 Transient Inhibition of Trastuzumab-Tumor Binding to Overcome the "Binding-Site Barrier" and Improve the Efficacy of a Trastuzumab-Gelonin Immunotoxin. Mol Cancer Ther. 2022 Oct 7;21(10):1573-1582.
Ref 2 Repurposing the Pentameric B-Subunit of Shiga Toxin for Gb3-Targeted Immunotherapy of Colorectal Cancer by Rhamnose Conjugation. J Pharm Sci. 2022 Oct;111(10):2719-2729.
Ref 3 Conjugation of Cetuximab - Puromycin and Its Target-Specific Effect on Triple Negative Breast Cancer Cell Lines. Asian Pac J Cancer Prev. 2022 May 1;23(5):1803-1812.
Ref 4 Preclinical Efficacy of Endoglin-Targeting Antibody-Drug Conjugates for the Treatment of Ewing Sarcoma. Clin Cancer Res. 2019 Apr 1;25(7):2228-2240. doi: 10.1158/1078-0432.CCR-18-0936. Epub 2018 Nov 12.
Ref 5 TAK-169, an exceptionally potent CD38 targeted engineered toxin body, as a novel direct cell kill approach for the treatment of multiple myeloma. Cancer Res (2019) 79 (13_Supplement): 2384.
Ref 6 A specific and potent immunotoxin composed of antibody ZME-018 and the plant toxin gelonin. Mol Biother. 1991 Mar;3(1):6-13.
Ref 7 Potentiation of antiproliferative effects of monoclonal antibody Lym-1 and immunoconjugate Lym-1-gelonin on human Burkitt's lymphoma cells with gamma-interferon and tumor necrosis factor. J Immunother Emphasis Tumor Immunol. 1995 Nov;18(4):221-30. doi: 10.1097/00002371-199511000-00003.
Ref 8 In vitro anti-tumour activity of anti-CD80 and anti-CD86 immunotoxins containing type 1 ribosome-inactivating proteins. Br J Haematol. 2000 Aug;110(2):351-61. doi: 10.1046/j.1365-2141.2000.02193.x.
Ref 9 Biotherapy of cancer by targeting TP-3/p80; 1996-07-18
Ref 10 Immunoconjugates that neutralize HIV virions kill T cells infected with diverse strains of HIV-1. J Immunol. 1990 Feb 15;144(4):1257-62.
Ref 11 Effects of therapy with T101 ricin A-chain immunotoxin in two leukemia patients. Blood. 1986 Jun;67(6):1680-7.
Ref 12 Suppression of an epidermal growth factor receptor-hyperproducing tumor by an immunotoxin conjugate of gelonin and a monoclonal anti-epidermal growth factor receptor antibody. Cancer Res. 1989 Dec 15;49(24 Pt 1):7106-9.