Target Information

General Information of This Target
Target ID
PATR0IMSYD
Target Name
Ribosome (RB)
Function
Ribosome (RB) are macromolecular machines, found within all cells, that perform biological protein synthesis (mRNA translation). Ribosomes link amino acids together in the order specified by the codons of messenger RNA (mRNA) molecules to form polypeptide chains. Ribosomes consist of two major components: the small and large ribosomal subunits. Each subunit consists of one or more ribosomal RNA (rRNA) molecules and many ribosomal proteins (RPs or r-proteins).

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Full List of The ADC Related to This Target
Phase 1
Click To Hide/Show 1 ADC Related to This Stage
ADC Info ADC Name Antibody Antigen Payload Linker Ref
 ADC Info 
MT-5111
Undisclosed
ERBB2
Shiga toxin B subunit (StxB)
Undisclosed
 [1]
Clinical candidate
Click To Hide/Show 4 ADC Related to This Stage
ADC Info ADC Name Antibody Antigen Payload Linker Ref
 ADC Info 
Monoclonal antibody ZME-018-gelonin conjugate
Murine mAb ZME-018
Undisclosed
Gelonin
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
 [2]
 ADC Info 
Monoclonal antibody LYM-1-gelonin conjugate
LYM-1
HLA-DRA
Gelonin
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
 [3]
 ADC Info 
Monoclonal antibody TP3-PAP conjugate
TP-3 murine mAb
TNFRSF1B
Pokeweed antiviral protein (PAP)
Undisclosed
 [4]
 ADC Info 
Telimomab aritox
Anti-CD5 mAb T101
CD5
Ricin A-chain
Undisclosed
 [5]
Investigative
Click To Hide/Show 7 ADC Related to This Stage
ADC Info ADC Name Antibody Antigen Payload Linker Ref
 ADC Info 
Cetuximab-Puromycin
Cetuximab
EGFR
Puromycin
Succinimidyl acetylthiopropionate (SATP)
 [6]
 ADC Info 
Trastuzumab-Gelonin
Trastuzumab
ERBB2
Gelonin
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 [7]
 ADC Info 
1B-3R ADC
Undisclosed
A4GALT
Shiga toxin B subunit (StxB)
Undisclosed
 [8]
 ADC Info 
OMTX-503
OMTX003
ENG
Nigrin b
Succynimidyloxycarbonyl-alpha-methyl-alpha-(2-pyridyl-dithio) toluene (SMPT)
 [9]
 ADC Info 
TAK-169
Undisclosed
CD38
Ribosome inactivating SLTA
Undisclosed
 [10]
 ADC Info 
Anti-B7-2-gelonin immunotoxin
Anti-CD86 mAb 1G10
CD86
Gelonin
Undisclosed
 [11]
 ADC Info 
BAT123-PAP-S
BAT 123
env
Pokeweed antiviral protein
Undisclosed
 [12]
Terminated
Click To Hide/Show 1 ADC Related to This Stage
ADC Info ADC Name Antibody Antigen Payload Linker Ref
 ADC Info 
Monoclonal antibody B4G7-gelonin conjugate
Anti-EGF murine mAb B4G7
EGF
Gelonin
Undisclosed
 [13]
References
Ref 1 Novel development strategies and challenges for anti-Her2 antibody-drug conjugates. Antib Ther. 2022 Jan 27;5(1):18-29. doi: 10.1093/abt/tbac001.
Ref 2 A specific and potent immunotoxin composed of antibody ZME-018 and the plant toxin gelonin. Mol Biother. 1991 Mar;3(1):6-13.
Ref 3 Potentiation of antiproliferative effects of monoclonal antibody Lym-1 and immunoconjugate Lym-1-gelonin on human Burkitt's lymphoma cells with gamma-interferon and tumor necrosis factor. J Immunother Emphasis Tumor Immunol. 1995 Nov;18(4):221-30. doi: 10.1097/00002371-199511000-00003.
Ref 4 Biotherapy of cancer by targeting TP-3/p80; 1996-07-18
Ref 5 Effects of therapy with T101 ricin A-chain immunotoxin in two leukemia patients. Blood. 1986 Jun;67(6):1680-7.
Ref 6 Conjugation of Cetuximab - Puromycin and Its Target-Specific Effect on Triple Negative Breast Cancer Cell Lines. Asian Pac J Cancer Prev. 2022 May 1;23(5):1803-1812.
Ref 7 Transient Inhibition of Trastuzumab-Tumor Binding to Overcome the "Binding-Site Barrier" and Improve the Efficacy of a Trastuzumab-Gelonin Immunotoxin. Mol Cancer Ther. 2022 Oct 7;21(10):1573-1582.
Ref 8 Repurposing the Pentameric B-Subunit of Shiga Toxin for Gb3-Targeted Immunotherapy of Colorectal Cancer by Rhamnose Conjugation. J Pharm Sci. 2022 Oct;111(10):2719-2729.
Ref 9 Preclinical Efficacy of Endoglin-Targeting Antibody-Drug Conjugates for the Treatment of Ewing Sarcoma. Clin Cancer Res. 2019 Apr 1;25(7):2228-2240. doi: 10.1158/1078-0432.CCR-18-0936. Epub 2018 Nov 12.
Ref 10 TAK-169, an exceptionally potent CD38 targeted engineered toxin body, as a novel direct cell kill approach for the treatment of multiple myeloma. Cancer Res (2019) 79 (13_Supplement): 2384.
Ref 11 In vitro anti-tumour activity of anti-CD80 and anti-CD86 immunotoxins containing type 1 ribosome-inactivating proteins. Br J Haematol. 2000 Aug;110(2):351-61. doi: 10.1046/j.1365-2141.2000.02193.x.
Ref 12 Immunoconjugates that neutralize HIV virions kill T cells infected with diverse strains of HIV-1. J Immunol. 1990 Feb 15;144(4):1257-62.
Ref 13 Suppression of an epidermal growth factor receptor-hyperproducing tumor by an immunotoxin conjugate of gelonin and a monoclonal anti-epidermal growth factor receptor antibody. Cancer Res. 1989 Dec 15;49(24 Pt 1):7106-9.

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