Payload Information
General Information of This Payload
| Payload ID | PAY0ZRVSM |
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| Name | ADC-C4 Payload |
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| Synonyms |
ADC-C4 Payload
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| Structure |
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| Formula | C28H27F2N3O6S2 |
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| Isosmiles | CC[C@@](C(C=C1C2=NC3=C4C([C@@H](NC(C(C)(F)CO)=O)CCC4=C(C)C(F)=C3)=C2CN51)=C(C5=O)CO6)(O)C6=O.[S].[S] |
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| InChI |
InChI=1S/C28H27F2N3O6.2S/c1-4-28(38)16-7-20-23-14(9-33(20)24(35)15(16)10-39-26(28)37)22-18(32-25(36)27(3,30)11-34)6-5-13-12(2)17(29)8-19(31-23)21(13)22;;/h7-8,18,34,38H,4-6,9-11H2,1-3H3,(H,32,36);;/t18-,27?,28-;;/m0../s1
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| InChIKey |
BONIMNPQJPJVKJ-QLCOYRSCSA-N
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| Pharmaceutical Properties | Molecule Weight |
603.669 |
Polar area |
130.75 |
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Complexity |
1631.464712 |
xlogp Value |
3.64752 |
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Heavy Count |
41 |
Rot Bonds |
4 |
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Hbond acc |
8 |
Hbond Donor |
3 |
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Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
WO2024110905A1 ADC-C4 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.018 nM
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Positive B7H3 expression (B7H3+++/++) | ||
| Method Description |
Adding the fresh growth-medium containing the varying concentrations of ADCs, 40ul/well
into H358, H441, H1048 and MDA-MB-487.
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| In Vitro Model | Lung small cell carcinoma, Small cell lung cancer | H1048 cells | CVCL_1453 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.022 nM
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High B7H3 expression (B7H3 +++) | ||
| Method Description |
Adding the fresh growth-medium containing the varying concentrations of ADCs, 40ul/well
into H358, H441, H1048 and MDA-MB-487.
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| In Vitro Model | Minimally invasive lung adenocarcinoma | H358 cells | CVCL_1559 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
2.291 nM
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Positive B7H3 expression (B7H3+++/++) | ||
| Method Description |
Adding the fresh growth-medium containing the varying concentrations of ADCs, 40ul/well
into H358, H441, H1048 and MDA-MB-487.
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| In Vitro Model | Lung papillary adenocarcinoma | H441 cells | CVCL_1561 | ||
| Experiment 4 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | > 100 nM | Negative B7H3 expression (B7H3-) | ||
| Method Description |
Adding the fresh growth-medium containing the varying concentrations of ADCs, 40ul/well
into H358, H441, H1048 and MDA-MB-487.
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| In Vitro Model | Breast adenocarcinoma | MDA-MB-453 cells | CVCL_0418 | ||
WO2024110905A1 ADC-C5 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.038 nM
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Positive B7H3 expression (B7H3+++/++) | ||
| Method Description |
Adding the fresh growth-medium containing the varying concentrations of ADCs, 40ul/well
into H358, H441, H1048 and MDA-MB-487.
|
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| In Vitro Model | Lung small cell carcinoma, Small cell lung cancer | H1048 cells | CVCL_1453 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
0.074 nM
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High B7H3 expression (B7H3 +++) | ||
| Method Description |
Adding the fresh growth-medium containing the varying concentrations of ADCs, 40ul/well
into H358, H441, H1048 and MDA-MB-487.
|
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| In Vitro Model | Minimally invasive lung adenocarcinoma | H358 cells | CVCL_1559 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) |
1.245 nM
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Positive B7H3 expression (B7H3+++/++) | ||
| Method Description |
Adding the fresh growth-medium containing the varying concentrations of ADCs, 40ul/well
into H358, H441, H1048 and MDA-MB-487.
|
||||
| In Vitro Model | Lung papillary adenocarcinoma | H441 cells | CVCL_1561 | ||
| Experiment 4 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | > 100 nM | Negative B7H3 expression (B7H3-) | ||
| Method Description |
Adding the fresh growth-medium containing the varying concentrations of ADCs, 40ul/well
into H358, H441, H1048 and MDA-MB-487.
|
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| In Vitro Model | Breast adenocarcinoma | MDA-MB-453 cells | CVCL_0418 | ||