Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0FAHYM
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| ADC Name |
WO2024110905A1 ADC-C4
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| Synonyms |
WO2024110905A1 ADC-C4
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| Organization |
BEIGENE, LTD. | BEIGENE SWITZERLAND GMBH
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| Drug Status |
Investigative
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| Drug-to-Antibody Ratio |
7.9
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| Structure |
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| Antibody Name |
undisclosed
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| Antigen Name |
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)
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Antigen Info | ||||
| Payload Name |
ADC-C4 Payload
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Payload Info | ||||
| Linker Name |
Linker of ADC2-51
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Linker Info | ||||
| Conjugate Type |
Random conjugation through reduced inter-chain cysteines.
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General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | 0.018 nM | Positive B7H3 expression (B7H3+++/++) | ||
| Method Description |
Adding the fresh growth-medium containing the varying concentrations of ADCs, 40ul/well
into H358, H441, H1048 and MDA-MB-487.
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| In Vitro Model | Lung small cell carcinoma, Small cell lung cancer | H1048 cells | CVCL_1453 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | 0.022 nM | High B7H3 expression (B7H3 +++) | ||
| Method Description |
Adding the fresh growth-medium containing the varying concentrations of ADCs, 40ul/well
into H358, H441, H1048 and MDA-MB-487.
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| In Vitro Model | Minimally invasive lung adenocarcinoma | H358 cells | CVCL_1559 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | 2.291 nM | Positive B7H3 expression (B7H3+++/++) | ||
| Method Description |
Adding the fresh growth-medium containing the varying concentrations of ADCs, 40ul/well
into H358, H441, H1048 and MDA-MB-487.
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| In Vitro Model | Lung papillary adenocarcinoma | H441 cells | CVCL_1561 | ||
| Experiment 4 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | > 100 nM | Negative B7H3 expression (B7H3-) | ||
| Method Description |
Adding the fresh growth-medium containing the varying concentrations of ADCs, 40ul/well
into H358, H441, H1048 and MDA-MB-487.
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| In Vitro Model | Breast adenocarcinoma | MDA-MB-453 cells | CVCL_0418 | ||