Payload Information

General Information of This Payload

Payload ID	PAY0MQSWH
Name	5T4-PBD
Synonyms	5T4 PBD; 5T4PBD Click to Show/Hide
Target(s)	Human Deoxyribonucleic acid (hDNA)			Target Info
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Each Antibody-drug Conjugate Related to This Payload

Full Information of The Activity Data of The ADC(s) Related to This Payload

MEDI-0641 [Clinical candidate]

ADC Info

Discovered Using Cell Line-derived Xenograft Model

Click To Hide/Show 1 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Tumor Growth Inhibition value (TGI)	≈ 91.30% (Day 49)	Positive 5T4 expression (5T4+++/++)
Method Description	A single dose of 5T4-PBD was administrated at 0.1 and 0.3 mg/kg intravenously into nude mice.
In Vivo Model	MDA-MB-361 CDX model
In Vitro Model	Breast adenocarcinoma	MDA-MB-361 cells		CVCL_0620

References

Ref 1	Improved Therapeutic Window in BRCA-mutant Tumors with Antibody-linked Pyrrolobenzodiazepine Dimers with and without PARP Inhibition. Mol Cancer Ther. 2019 Jan;18(1):89-99. doi: 10.1158/1535-7163.MCT-18-0314. Epub 2018 Oct 23.

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