Payload Information
General Information of This Payload
| Payload ID | PAY0MQSWH |
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| Name | 5T4-PBD |
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| Synonyms |
5T4 PBD; 5T4PBD
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| Target | Human Deoxyribonucleic acid (hDNA) | |||||
Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
MEDI-0641 [Clinical candidate]
Discovered Using Cell Line-derived Xenograft Model
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 91.30% | Positive 5T4 expression (5T4+++/++) | ||
| Method Description |
A single dose of 5T4-PBD was administrated at 0.1 and 0.3 mg/kg intravenously into nude mice.
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| In Vivo Model | MDA-MB-361 CDX model | ||||
| In Vitro Model | Breast adenocarcinoma | MDA-MB-361 cells | CVCL_0620 | ||
References