General Information of This Payload
Payload ID
PAY0AQYPA
Name
DNA-damaging alkylating agent
Synonyms
DNA-damaging alkylating agent
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Target(s) Human Deoxyribonucleic acid (hDNA)
The activity data of This Payload
Standard Type Value Units Cell line Disease Model Cell line ID Reference
Half Maximal Inhibitory Concentration (IC50) 0.000000002 M
NCI-H2110 cells
Lung non-small cell carcinoma
CVCL_1530 
[1]
Half Maximal Inhibitory Concentration (IC50) 0.000000003 M
T-47D cells
Invasive breast carcinoma
CVCL_0553 
[1]
Half Maximal Inhibitory Concentration (IC50) 0.000000005 M
KB cells
Human papillomavirus-related endocervical adenocarcinoma
CVCL_0372 
[1]
Each Antibody-drug Conjugate Related to This Payload
References
Ref 1 Site-Specific Conjugation of the Indolinobenzodiazepine DGN549 to Antibodies Affords Antibody-Drug Conjugates with an Improved Therapeutic Index as Compared with Lysine Conjugation. Bioconjug Chem. 2020 Jan 15;31(1):93-103.