Antibody Information
General Information of This Antibody (ID: ANTI0VNMLT)
| Antibody Name | h7D9.v3 |
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| Antigen Name | MSLN |
Antigen Info | ||||
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Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
RG7600 [Phase 1 (discontinued)]
Identified from the Human Clinical Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Patients Enrolled |
Histologically documented, incurable, locally advanced or metastatic disease for which no standard therapy exists, consisting of one of the following: Unresectable pancreatic ductal adenocarcinoma or platinum-resistant ovarian cancer
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| Administration Dosage |
Injection of 89Zr-MMOT0530A followed by 2 or 3 PET scans at different time points
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| Related Clinical Trial | |||||
| NCT Number | NCT01832116 | Clinical Status | PHASE1 | ||
| Clinical Description |
89Zr-MMOT0530A PET Imaging in Patients With Unresectable Pancreatic or Platinum-resistant Ovarian Cancer Before Treatment With DMOT4039A. A Separate Study to the Phase I Study Protocol DMO4993g
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| Primary Endpoint |
The in vivo biodistribution measured in SUV values and organ pharmacokinetics (PK) of 89Zr-MMOT0530A [Time Frame: Approximately 1 year]
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| Other Endpoint |
The 89Zr-MMOT0530A tumor uptake measured in SUV related to the response to DMOT4039A therapy according to RECISt 1.1 criteria [Time Frame: Approximately 1 year], Number of patients with adverse events after 89Zr-MMOT0530A injection as a measure of safety and tolerability [Time Frame: Approximately 1 year]
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| Experiment 2 Reporting the Activity Date of This ADC | [2] | ||||
| Patients Enrolled |
Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1.Histologically documented, incurable, locally advanced or metastatic disease for which no standard therapy exists, consisting of one of the following: Unresectable pancreatic ductal adenocarcinoma or platinum-resistant ovarian cancer.
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| Administration Dosage |
Participants in different cohorts will receive DMOT4039A at various escalating dose levels, starting with 0.2 milligrams per kilogram (mg/kg), as intravenous infusion every 3 weeks (Q3W) to determine the maximum tolerated dose (MTD) of DMOT4039A for until disease progression, loss of clinical benefit or unacceptable toxicity, whichever occurred first (up to approximately 2.5 years
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| Related Clinical Trial | |||||
| NCT Number | NCT01469793 | Clinical Status | PHASE1 | ||
| Clinical Description |
A Phase I, Open Label Study of the Safety and Pharmacokinetics of Escalating Doses of DMOT4039A in Patients With Unresectable Pancreatic or Platinum-Resistant Ovarian Cancer
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| Primary Endpoint |
Maximum Tolerated Dose (MTD) of DMOT4039A, Number of Participants With Dose-Limiting Toxicities (DLTs), Recommended Phase 2 Dose (RP2D) of DMOT4039A.
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| Other Endpoint |
Pharmacokinetics: area under the concentration-time curve (AUC), Serum anti-therapeutic antibody levels, Objective response (complete response or partial response), tumor assessments according to RECIST criteria, Duration of response, Progression-free survival.
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References