Antibody Information
General Information of This Antibody
| Antibody ID | ANI0VQKBT |
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|---|---|---|---|---|---|---|
| Antibody Name | U3-1784 |
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| Antibody Type | Monoclonal antibody (mAb) |
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| Antibody Subtype | Humanized IgG1-kappa |
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| Antigen Name | Fibroblast growth factor receptor 4 (FGFR4) |
Antigen Info | ||||
Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
U3-1784-Compound (Ia) [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
17.03 pM
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Positive FGFR4 expression (FGFR4+++/++) | ||
| Method Description |
Cells were plated at about 500 cells per well in a 96-well plate in 100 uL of media. In vitro activity and targeted delivery of ADCs, the isotype-matched negative controls ADCs, and naked antibodies control were assessed in cells.
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| In Vitro Model | Alveolar rhabdomyosarcoma | Rh41 cells | CVCL_2176 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
20.52 pM
|
Positive FGFR4 expression (FGFR4+++/++) | ||
| Method Description |
Cells were plated at about 500 cells per well in a 96-well plate in 100 uL of media. In vitro activity and targeted delivery of ADCs, the isotype-matched negative controls ADCs, and naked antibodies control were assessed in cells.
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| In Vitro Model | Alveolar rhabdomyosarcoma | Rh30 cells | CVCL_0041 | ||
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