Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)

ADC ID	DRG0FIZST
ADC Name	U3-1784-Compound (Ia)
Synonyms	U3-1784 Compound (Ia) Click to Show/Hide
Organization	Orum Therapeutics, Inc.
Drug Status	Investigative
Indication	In total 1 Indication(s) Rhabdomyosarcoma [ICD11:2B55] Investigative
Drug-to-Antibody Ratio	8
Structure
	3D MOL	2D MOL
Antibody Name	U3-1784		Antibody Info
Antigen Name	Fibroblast growth factor receptor 4 (FGFR4)		Antigen Info
Payload Name	NeoDegrader P1		Payload Info
Therapeutic Target	Protein cereblon (CRBN)		Target Info
Linker Name	U3-1784-Compound (Ia) linker

General Information of The Activity Data Related to This ADC

Revealed Based on the Cell Line Data

Click To Hide/Show 2 Activity Data Related to This Level

Standard Type	Value	Units	Cell Line	Disease Model
Half Maximal Inhibitory Concentration (IC50)	17.03	pM	Rh41 cells	Alveolar rhabdomyosarcoma
Half Maximal Inhibitory Concentration (IC50)	20.52	pM	Rh30 cells	Alveolar rhabdomyosarcoma

Full List of Activity Data of This Antibody-drug Conjugate

Revealed Based on the Cell Line Data

Click To Hide/Show 2 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	17.03 pM	Positive FGFR4 expression (FGFR4+++/++)
Method Description	Cells were plated at about 500 cells per well in a 96-well plate in 100 uL of media. In vitro activity and targeted delivery of ADCs, the isotype-matched negative controls ADCs, and naked antibodies control were assessed in cells.
In Vitro Model	Alveolar rhabdomyosarcoma	Rh41 cells		CVCL_2176
Experiment 2 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal Inhibitory Concentration (IC50)	20.52 pM	Positive FGFR4 expression (FGFR4+++/++)
Method Description	Cells were plated at about 500 cells per well in a 96-well plate in 100 uL of media. In vitro activity and targeted delivery of ADCs, the isotype-matched negative controls ADCs, and naked antibodies control were assessed in cells.
In Vitro Model	Alveolar rhabdomyosarcoma	Rh30 cells		CVCL_0041

References

Ref 1	Neodegrader conjugates; 2021-10-07.