Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ID: DRG0YZAEQ)
ADC Name
US12144865B2 2k*;
Synonyms
US12144865B2 2k*
   Click to Show/Hide
Organization
BAYER PHARMA AKTIENGESELLSCHAFT
Drug Status
Investigative
Drug-to-Antibody Ratio
3.7
Structure
Antibody Name
TPP-2658
  Antibody Info 
Antigen Name
Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A)
  Antigen Info 
Payload Name
Undisclosed
Linker Name
Undisclosed
Conjugate Type
Random conjugation through reduced inter-chain cysteines.
General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Click To Hide/Show 3 Activity Data Related to This Level
Standard Type Value Units Cell Line Disease Model
Half Maximal inhibitory Concentration (IC50)Human PBMC 
0.285
nM
CVCL_0399
Colon adenocarcinoma
Half Maximal inhibitory Concentration (IC50)Human PBMC 
0.845
nM
CVCL_0455
Lung mucoepidermoid carcinoma
Half Maximal inhibitory Concentration (IC50)Human PBMC 
2.16
nM
CVCL_0186
Pancreatic ductal adenocarcinoma
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
Click To Hide/Show 3 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (IC50)Human PBMC 0.285 nM Positive TNFRSF12A expression (TNFRSF12A+++/++)
Method Description
Tables 1b and 1c below set out the IC50 values for representative working examples from this assay
In Vitro Model Colon adenocarcinoma LoVo cells CVCL_0399
Experiment 2 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (IC50)Human PBMC 0.845 nM Positive TNFRSF12A expression (TNFRSF12A+++/++)
Method Description
Tables 1b and 1c below set out the IC50 values for representative working examples from this assay
In Vitro Model Lung mucoepidermoid carcinoma NCI-H292 cells CVCL_0455
Experiment 3 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (IC50)Human PBMC 2.16 nM Positive TNFRSF12A expression (TNFRSF12A+++/++)
Method Description
Tables 1b and 1c below set out the IC50 values for representative working examples from this assay
In Vitro Model Pancreatic ductal adenocarcinoma BxPC-3 cells CVCL_0186
References
Ref 1 Antibody drug conjugates with enzymatically cleavable groups