Antigen Information

General Information of This Antigen (ID: TAR0DBBHK)
Antigen Name
Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A)
Gene Name
TNFRSF12A
Gene ID
51330
Synonym
FN14; Fibroblast growth factor-inducible immediate-early response protein 14;Tweak-receptor;CD266
Sequence
MARGSLRRLLRLLVLGLWLALLRSVAGEQAPGTAPCSRGSSWSADLDKCMDCASCRARPH
SDFCLGCAAAPPAPFRLLWPILGGALSLTFVLGLLSGFLVWRRCRRREKFTTPIEETGGE
GCPAVALIQ

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Function
Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.

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Uniprot Entry
TNR12_HUMAN
HGNC ID
HGNC:18152
KEGG ID
hsa:51330
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
ADC Name Payload Target Linker ADC Info
WO2024105205A1 11k-2090a* [1]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
WO2024105205A1 1k-7007 [1]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 2k-7007 [1]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 3k-7007 [1]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 4k-7007 [1]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 5k-7007 [1]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 6k-7007 [1]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 7k-7007 [1]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 8k-7007 [1]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 11k-7007a [1]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 11k-7007b [1]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 12k-7007a 1 [1]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 12k-7007a 2 [1]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 13k-7007 [1]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 14k-7007 [1]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
WO2024105205A1 1k-7007* [1]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 2k-7007* [1]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
Anti-TWEAKR mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
TWEAKR-KSP-ADC 1.1 [2]
Pyrrole based kinesin spindle protein inhibitor
Kinesin-like protein KIF11 (KIF11)
Kinesin spindle protein inhibitor (KSPi)-ADC linker 1
 ADC Info 
TWEAKR-KSP-ADC 1.2 [2]
Pyrrole based kinesin spindle protein inhibitor
Kinesin-like protein KIF11 (KIF11)
Kinesin spindle protein inhibitor (KSPi)-ADC linker 2
 ADC Info 
TWEAKR-KSP-ADC 1.3 [2]
Pyrrole based kinesin spindle protein inhibitor
Kinesin-like protein KIF11 (KIF11)
Kinesin spindle protein inhibitor (KSPi)-ADC linker 3
 ADC Info 
TWEAKR-KSP-ADC 1.4 [2]
Pyrrole based kinesin spindle protein inhibitor
Kinesin-like protein KIF11 (KIF11)
Kinesin spindle protein inhibitor (KSPi)-ADC linker 4
 ADC Info 
TWEAKR-KSP-ADC 2.1 [2]
Pyrrole based kinesin spindle protein inhibitor
Kinesin-like protein KIF11 (KIF11)
Kinesin spindle protein inhibitor (KSPi)-ADC linker 5
 ADC Info 
TWEAKR-KSP-ADC 2.2 [2]
Pyrrole based kinesin spindle protein inhibitor
Kinesin-like protein KIF11 (KIF11)
Kinesin spindle protein inhibitor (KSPi)-ADC linker 6
 ADC Info 
CN114917361A ADC-4 [3]
CN114917361A ADC-4 payload
Undisclosed
CN114917361A ADC-4 linker
 ADC Info 
CN114917361A ADC-5 [3]
CN114917361A ADC-5 payload
Undisclosed
CN114917361A ADC-5 linker
 ADC Info 
CN114917361A ADC-8 [3]
CN114917361A ADC-8 payload
Undisclosed
CN114917361A ADC-8 linker
 ADC Info 
CN114917361A ADC-9 [3]
CN114917361A ADC-9 payload
Undisclosed
CN114917361A ADC-9 linker
 ADC Info 
CN114917361A ADC-10 [3]
CN114917361A ADC-10 payload
Undisclosed
CN114917361A ADC-10 linker
 ADC Info 
CN114917361A ADC-12 [3]
CN114917361A ADC-12 payload
Undisclosed
CN114917361A ADC-12 linker
 ADC Info 
CN114917361A ADC-15 [3]
CN114917361A ADC-15 payload
Undisclosed
CN114917361A ADC-15 linker
 ADC Info 
CN114917361A ADC-18 [3]
CN114917361A ADC-18 payload
Undisclosed
CN114917361A ADC-18 linker
 ADC Info 
CN114917361A ADC-20 [3]
CN114917361A ADC-20 payload
Undisclosed
CN114917361A ADC-20 linker
 ADC Info 
CN114917361A ADC-23 [3]
CN114917361A ADC-23 payload
Undisclosed
CN114917361A ADC-23 linker
 ADC Info 
CN114917361A ADC-24 [3]
CN114917361A ADC-24 payload
Undisclosed
CN114917361A ADC-24 linker
 ADC Info 
CN114917361A ADC-26 [3]
CN114917361A ADC-26 payload
Undisclosed
CN114917361A ADC-26 linker
 ADC Info 
CN114917361A ADC-29 [3]
CN114917361A ADC-29 payload
Undisclosed
CN114917361A ADC-29 linker
 ADC Info 
CN114917361A ADC-32 [3]
CN114917361A ADC-32 payload
Undisclosed
CN114917361A ADC-32 linker
 ADC Info 
CN114917361A ADC-35 [3]
CN114917361A ADC-35 payload
Undisclosed
CN114917361A ADC-35 linker
 ADC Info 
CN114917361A ADC-38 [3]
CN114917361A ADC-38 payload
Undisclosed
CN114917361A ADC-38 linker
 ADC Info 
CN114917361A ADC-40 [3]
CN114917361A ADC-40 payload
Undisclosed
CN114917361A ADC-40 linker
 ADC Info 
CN114917361A ADC-43 [3]
CN114917361A ADC-43 payload
Undisclosed
CN114917361A ADC-43 linker
 ADC Info 
CN114917361A ADC-46 [3]
CN114917361A ADC-46 payload
Undisclosed
CN114917361A ADC-46 linker
 ADC Info 
CN114917361A ADC-49 [3]
CN114917361A ADC-49 payload
Undisclosed
CN114917361A ADC-49 linker
 ADC Info 
CN114917361A ADC-52 [3]
CN114917361A ADC-52 payload
Undisclosed
CN114917361A ADC-52 linker
 ADC Info 
CN114917361A ADC-53 [3]
CN114917361A ADC-53 payload
Undisclosed
CN114917361A ADC-53 linker
 ADC Info 
CN114917361A ADC-54 [3]
CN114917361A ADC-54 payload
Undisclosed
CN114917361A ADC-54 linker
 ADC Info 
CN114917361A ADC-57 [3]
CN114917361A ADC-57 payload
Undisclosed
CN114917361A ADC-57 linker
 ADC Info 
CN114917361A ADC-60 [3]
CN114917361A ADC-60 payload
Undisclosed
CN114917361A ADC-60 linker
 ADC Info 
CN114917361A ADC-63 [3]
CN114917361A ADC-63 payload
Undisclosed
CN114917361A ADC-63 linker
 ADC Info 
CN114917361A ADC-66 [3]
CN114917361A ADC-66 payload
Undisclosed
CN114917361A ADC-66 linker
 ADC Info 
CN114917361A ADC-69 [3]
CN114917361A ADC-69 payload
Undisclosed
CN114917361A ADC-69 linker
 ADC Info 
CN114917361A ADC-72 [3]
CN114917361A ADC-72 payload
Undisclosed
CN114917361A ADC-72 linker
 ADC Info 
CN114917361A ADC-75 [3]
CN114917361A ADC-75 payload
Undisclosed
CN114917361A ADC-75 linker
 ADC Info 
CN114917361A ADC-78 [3]
CN114917361A ADC-78 payload
Undisclosed
CN114917361A ADC-78 linker
 ADC Info 
CN114917361A ADC-81 [3]
CN114917361A ADC-81 payload
Undisclosed
CN114917361A ADC-81 linker
 ADC Info 
CN114917361A ADC-84 [3]
CN114917361A ADC-84 payload
Undisclosed
CN114917361A ADC-84 linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
TWEAKR-KSPi-ADC2 [4]
KSP inhibitor
Kinesin-like protein KIF11 (KIF11)
Mc-peptide-based linker
 ADC Info 
TWEAKR-KSPi-ADC1 [4]
KSP inhibitor
Kinesin-like protein KIF11 (KIF11)
Glutaricacid-peptide-based linker
 ADC Info 
TWEAKR ADC 3a [5]
Kinesin spindle protein (KSP) inhibitor 3a
Kinesin-like protein KIF11 (KIF11)
Open-chain glycine maleimide
 ADC Info 
TWEAKR ADC 3b [5]
Kinesin spindle protein (KSP) inhibitor 3b
Kinesin-like protein KIF11 (KIF11)
Open-chain glycine maleimide
 ADC Info 
TWEAKR ADC 3c [5]
Kinesin spindle protein (KSP) inhibitor 3c
Kinesin-like protein KIF11 (KIF11)
Open-chain glycine maleimide
 ADC Info 
TWEAKR ADC 3d [5]
Kinesin spindle protein (KSP) inhibitor 3d
Kinesin-like protein KIF11 (KIF11)
Open-chain glycine maleimide
 ADC Info 
TWEAKR ADC 3e [5]
Kinesin spindle protein (KSP) inhibitor 3e
Kinesin-like protein KIF11 (KIF11)
Open-chain glycine maleimide
 ADC Info 
TWEAKR ADC 3f [5]
Kinesin spindle protein (KSP) inhibitor 3f
Kinesin-like protein KIF11 (KIF11)
Open-chain glycine maleimide
 ADC Info 
TWEAKR ADC 3g [5]
Kinesin spindle protein (KSP) inhibitor 3g
Kinesin-like protein KIF11 (KIF11)
Open-chain glycine maleimide
 ADC Info 
ADC Name Payload Target Linker ADC Info
US12144865B2 1k [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 1k*; [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 2k [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 2k*; [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 3k [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 4k [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 5k [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 6k [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 7k [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 8k [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 9k [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 10k [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 11k [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 12k [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 13k [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 14k [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 15k [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 16k [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 17k [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 18k [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 19k [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 20k [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 20k*; [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 21k [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 22k [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 23k [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 24k [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 25k [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 26k [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 27k [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 28k [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 29k [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 30k [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 31t [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 32t [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 33 [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 35k [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 36k [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 37k [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 38k [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US121US12144865B2 4US12144865B2 4865B2 39k [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 40k [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 41k [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 42k [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 43k [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 44k [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024105206A1 1k-2658 [7]
CHH0170, 1i-5657, Payload
Undisclosed
32p-Avelu Linker
 ADC Info 
WO2024105206A1 2k-2658 [7]
Camptothecin
DNA topoisomerase 1 (TOP1)
2i-5657 Linker
 ADC Info 
WO2024105206A1 3k-2658 [7]
Ac-Exatecan
DNA topoisomerase I (TOP1)
32p-Avelu Linker
 ADC Info 
WO2024105206A1 4k-2658 [7]
CHH0177, 4i-5657, Payload
Undisclosed
CHH0177, 4i-5657, Linker
 ADC Info 
WO2024105206A1 5k-2658 [7]
6i-5657 Payload
DNA topoisomerase I (TOP1)
3i-5657 Linker
 ADC Info 
WO2024105206A1 6k-2658 [7]
6i-5657 Payload
DNA topoisomerase I (TOP1)
3i-5657 Linker
 ADC Info 
WO2024105206A1 7k-2658 [7]
CHH0183, 7i-5657, Payload
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 11k-2658a* [1]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
References
Ref 1 Antibody-drug conjugates (A2DCs) with enzymatically cleavable groups
Ref 2 Antibody-Drug Conjugates with Pyrrole-Based KSP Inhibitors as the Payload Class. Angew Chem Int Ed Engl. 2018 Nov 12;57(46):15243-15247. doi: 10.1002/anie.201807619. Epub 2018 Oct 15.
Ref 3 Binder-wirkstoff-konjugate (adcs) und binder-prodrug-konjugate (apdcs) mit enzymatisch spaltbaren gruppen.
Ref 4 Antibody-drug conjugates harboring a kinesin spindle protein inhibitor with immunostimulatory properties. Oncoimmunology. 2022 Feb 9;11(1):2037216. doi: 10.1080/2162402X.2022.2037216. eCollection 2022.
Ref 5 Antibody-Prodrug Conjugates with KSP Inhibitors and Legumain-Mediated Metabolite Formation. Chemistry. 2019 Jun 21;25(35):8208-8213. doi: 10.1002/chem.201900441. Epub 2019 Apr 15.
Ref 6 Antibody drug conjugates with enzymatically cleavable groups
Ref 7 Antibody-drug conjugates cleavable in a tumor microenvironment