Antigen Information

General Information of This Antigen

Antigen ID	TAR0DBBHK
Antigen Name	Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A)
Gene Name	TNFRSF12A
Gene ID	51330
Synonym	FN14; Fibroblast growth factor-inducible immediate-early response protein 14;Tweak-receptor;CD_antigen=CD266
Sequence	MARGSLRRLLRLLVLGLWLALLRSVAGEQAPGTAPCSRGSSWSADLDKCMDCASCRARPH SDFCLGCAAAPPAPFRLLWPILGGALSLTFVLGLLSGFLVWRRCRRREKFTTPIEETGGE GCPAVALIQ Click to Show/Hide
Function	Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. Click to Show/Hide
Uniprot Entry	TNR12_HUMAN
HGNC ID	HGNC:18152
KEGG ID	hsa:51330

Each Antibody-drug Conjuate AND It's Component Related to This Antigen

Full List of The ADC Related to This Antigen

2090a

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	WO2024105205A1 11k-2090a*	KSPI6-1	Undisclosed	Undisclosed	[1]

7007

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	WO2024105205A1 1k-7007	KSPI6-1	Undisclosed	Undisclosed	[1]
ADC Info	WO2024105205A1 2k-7007	KSPI6-1	Undisclosed	Undisclosed	[1]
ADC Info	WO2024105205A1 3k-7007	KSPI6-1	Undisclosed	Undisclosed	[1]
ADC Info	WO2024105205A1 4k-7007	KSPI6-1	Undisclosed	Undisclosed	[1]
ADC Info	WO2024105205A1 5k-7007	KSPI6-1	Undisclosed	Undisclosed	[1]
ADC Info	WO2024105205A1 6k-7007	KSPI6-1	Undisclosed	Undisclosed	[1]
ADC Info	WO2024105205A1 7k-7007	KSPI6-1	Undisclosed	Undisclosed	[1]
ADC Info	WO2024105205A1 8k-7007	KSPI6-1	Undisclosed	Undisclosed	[1]
ADC Info	WO2024105205A1 11k-7007a	KSPI6-1	Undisclosed	Undisclosed	[1]
ADC Info	WO2024105205A1 11k-7007b	KSPI6-1	Undisclosed	Undisclosed	[1]
ADC Info	WO2024105205A1 12k-7007a 1	KSPI6-1	Undisclosed	Undisclosed	[1]
ADC Info	WO2024105205A1 12k-7007a 2	KSPI6-1	Undisclosed	Undisclosed	[1]
ADC Info	WO2024105205A1 13k-7007	KSPI6-1	Undisclosed	Undisclosed	[1]
ADC Info	WO2024105205A1 14k-7007	KSPI6-1	Undisclosed	Undisclosed	[1]

7007*

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	WO2024105205A1 1k-7007*	KSPI6-1	Undisclosed	Undisclosed	[1]
ADC Info	WO2024105205A1 2k-7007*	KSPI6-1	Undisclosed	Undisclosed	[1]

Anti-TWEAKR mAb

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	TWEAKR-KSP-ADC 1.1	Pyrrole based kinesin spindle protein inhibitor	Kinesin-like protein KIF11 (KIF11)	Kinesin spindle protein inhibitor (KSPi)-ADC linker 1	[2]
ADC Info	TWEAKR-KSP-ADC 1.2	Pyrrole based kinesin spindle protein inhibitor	Kinesin-like protein KIF11 (KIF11)	Kinesin spindle protein inhibitor (KSPi)-ADC linker 2	[2]
ADC Info	TWEAKR-KSP-ADC 1.3	Pyrrole based kinesin spindle protein inhibitor	Kinesin-like protein KIF11 (KIF11)	Kinesin spindle protein inhibitor (KSPi)-ADC linker 3	[2]
ADC Info	TWEAKR-KSP-ADC 1.4	Pyrrole based kinesin spindle protein inhibitor	Kinesin-like protein KIF11 (KIF11)	Kinesin spindle protein inhibitor (KSPi)-ADC linker 4	[2]
ADC Info	TWEAKR-KSP-ADC 2.1	Pyrrole based kinesin spindle protein inhibitor	Kinesin-like protein KIF11 (KIF11)	Kinesin spindle protein inhibitor (KSPi)-ADC linker 5	[2]
ADC Info	TWEAKR-KSP-ADC 2.2	Pyrrole based kinesin spindle protein inhibitor	Kinesin-like protein KIF11 (KIF11)	Kinesin spindle protein inhibitor (KSPi)-ADC linker 6	[2]
ADC Info	CN114917361A ADC-4	CN114917361A ADC-4 payload	Undisclosed	CN114917361A ADC-4 linker	[3]
ADC Info	CN114917361A ADC-5	CN114917361A ADC-5 payload	Undisclosed	CN114917361A ADC-5 linker	[3]
ADC Info	CN114917361A ADC-8	CN114917361A ADC-8 payload	Undisclosed	CN114917361A ADC-8 linker	[3]
ADC Info	CN114917361A ADC-9	CN114917361A ADC-9 payload	Undisclosed	CN114917361A ADC-9 linker	[3]
ADC Info	CN114917361A ADC-10	CN114917361A ADC-10 payload	Undisclosed	CN114917361A ADC-10 linker	[3]
ADC Info	CN114917361A ADC-12	CN114917361A ADC-12 payload	Undisclosed	CN114917361A ADC-12 linker	[3]
ADC Info	CN114917361A ADC-15	CN114917361A ADC-15 payload	Undisclosed	CN114917361A ADC-15 linker	[3]
ADC Info	CN114917361A ADC-18	CN114917361A ADC-18 payload	Undisclosed	CN114917361A ADC-18 linker	[3]
ADC Info	CN114917361A ADC-20	CN114917361A ADC-20 payload	Undisclosed	CN114917361A ADC-20 linker	[3]
ADC Info	CN114917361A ADC-23	CN114917361A ADC-23 payload	Undisclosed	CN114917361A ADC-23 linker	[3]
ADC Info	CN114917361A ADC-24	CN114917361A ADC-24 payload	Undisclosed	CN114917361A ADC-24 linker	[3]
ADC Info	CN114917361A ADC-26	CN114917361A ADC-26 payload	Undisclosed	CN114917361A ADC-26 linker	[3]
ADC Info	CN114917361A ADC-29	CN114917361A ADC-29 payload	Undisclosed	CN114917361A ADC-29 linker	[3]
ADC Info	CN114917361A ADC-32	CN114917361A ADC-32 payload	Undisclosed	CN114917361A ADC-32 linker	[3]
ADC Info	CN114917361A ADC-35	CN114917361A ADC-35 payload	Undisclosed	CN114917361A ADC-35 linker	[3]
ADC Info	CN114917361A ADC-38	CN114917361A ADC-38 payload	Undisclosed	CN114917361A ADC-38 linker	[3]
ADC Info	CN114917361A ADC-40	CN114917361A ADC-40 payload	Undisclosed	CN114917361A ADC-40 linker	[3]
ADC Info	CN114917361A ADC-43	CN114917361A ADC-43 payload	Undisclosed	CN114917361A ADC-43 linker	[3]
ADC Info	CN114917361A ADC-46	CN114917361A ADC-46 payload	Undisclosed	CN114917361A ADC-46 linker	[3]
ADC Info	CN114917361A ADC-49	CN114917361A ADC-49 payload	Undisclosed	CN114917361A ADC-49 linker	[3]
ADC Info	CN114917361A ADC-52	CN114917361A ADC-52 payload	Undisclosed	CN114917361A ADC-52 linker	[3]
ADC Info	CN114917361A ADC-53	CN114917361A ADC-53 payload	Undisclosed	CN114917361A ADC-53 linker	[3]
ADC Info	CN114917361A ADC-54	CN114917361A ADC-54 payload	Undisclosed	CN114917361A ADC-54 linker	[3]
ADC Info	CN114917361A ADC-57	CN114917361A ADC-57 payload	Undisclosed	CN114917361A ADC-57 linker	[3]
ADC Info	CN114917361A ADC-60	CN114917361A ADC-60 payload	Undisclosed	CN114917361A ADC-60 linker	[3]
ADC Info	CN114917361A ADC-63	CN114917361A ADC-63 payload	Undisclosed	CN114917361A ADC-63 linker	[3]
ADC Info	CN114917361A ADC-66	CN114917361A ADC-66 payload	Undisclosed	CN114917361A ADC-66 linker	[3]
ADC Info	CN114917361A ADC-69	CN114917361A ADC-69 payload	Undisclosed	CN114917361A ADC-69 linker	[3]
ADC Info	CN114917361A ADC-72	CN114917361A ADC-72 payload	Undisclosed	CN114917361A ADC-72 linker	[3]
ADC Info	CN114917361A ADC-75	CN114917361A ADC-75 payload	Undisclosed	CN114917361A ADC-75 linker	[3]
ADC Info	CN114917361A ADC-78	CN114917361A ADC-78 payload	Undisclosed	CN114917361A ADC-78 linker	[3]
ADC Info	CN114917361A ADC-81	CN114917361A ADC-81 payload	Undisclosed	CN114917361A ADC-81 linker	[3]
ADC Info	CN114917361A ADC-84	CN114917361A ADC-84 payload	Undisclosed	CN114917361A ADC-84 linker	[3]

BAY-356

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	TWEAKR-KSPi-ADC2	KSP inhibitor	Kinesin-like protein KIF11 (KIF11)	Mc-peptide-based linker	[4]
ADC Info	TWEAKR-KSPi-ADC1	KSP inhibitor	Kinesin-like protein KIF11 (KIF11)	Glutaricacid-peptide-based linker	[4]
ADC Info	TWEAKR ADC 3a	Kinesin spindle protein (KSP) inhibitor 3a	Kinesin-like protein KIF11 (KIF11)	Open-chain glycine maleimide	[5]
ADC Info	TWEAKR ADC 3b	Kinesin spindle protein (KSP) inhibitor 3b	Kinesin-like protein KIF11 (KIF11)	Open-chain glycine maleimide	[5]
ADC Info	TWEAKR ADC 3c	Kinesin spindle protein (KSP) inhibitor 3c	Kinesin-like protein KIF11 (KIF11)	Open-chain glycine maleimide	[5]
ADC Info	TWEAKR ADC 3d	Kinesin spindle protein (KSP) inhibitor 3d	Kinesin-like protein KIF11 (KIF11)	Open-chain glycine maleimide	[5]
ADC Info	TWEAKR ADC 3e	Kinesin spindle protein (KSP) inhibitor 3e	Kinesin-like protein KIF11 (KIF11)	Open-chain glycine maleimide	[5]
ADC Info	TWEAKR ADC 3f	Kinesin spindle protein (KSP) inhibitor 3f	Kinesin-like protein KIF11 (KIF11)	Open-chain glycine maleimide	[5]
ADC Info	TWEAKR ADC 3g	Kinesin spindle protein (KSP) inhibitor 3g	Kinesin-like protein KIF11 (KIF11)	Open-chain glycine maleimide	[5]

TPP-2658

Antibody Info

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	US12144865B2 1k	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 1k*;	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 2k	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 2k*;	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 3k	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 4k	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 5k	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 6k	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 7k	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 8k	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 9k	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 10k	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 11k	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 12k	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 13k	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 14k	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 15k	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 16k	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 17k	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 18k	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 19k	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 20k	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 20k*;	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 21k	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 22k	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 23k	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 24k	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 25k	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 26k	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 27k	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 28k	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 29k	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 30k	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 31t	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 32t	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 33	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 35k	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 36k	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 37k	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 38k	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US121US12144865B2 4US12144865B2 4865B2 39k	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 40k	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 41k	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 42k	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 43k	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	US12144865B2 44k	Undisclosed	Undisclosed	Undisclosed	[6]
ADC Info	WO2024105206A1 1k-2658	CHH0170, 1i-5657, Payload	Undisclosed	32p-Avelu Linker	[7]
ADC Info	WO2024105206A1 2k-2658	Camptothecin	DNA topoisomerase 1 (TOP1)	2i-5657 Linker	[7]
ADC Info	WO2024105206A1 3k-2658	Ac-Exatecan	DNA topoisomerase I (TOP1)	32p-Avelu Linker	[7]
ADC Info	WO2024105206A1 4k-2658	CHH0177, 4i-5657, Payload	Undisclosed	CHH0177, 4i-5657, Linker	[7]
ADC Info	WO2024105206A1 5k-2658	6i-5657 Payload	DNA topoisomerase I (TOP1)	3i-5657 Linker	[7]
ADC Info	WO2024105206A1 6k-2658	6i-5657 Payload	DNA topoisomerase I (TOP1)	3i-5657 Linker	[7]
ADC Info	WO2024105206A1 7k-2658	CHH0183, 7i-5657, Payload	Undisclosed	Undisclosed	[7]
ADC Info	WO2024105205A1 11k-2658a*	KSPI6-1	Undisclosed	Undisclosed	[1]

References

Ref 1	Antibody-drug conjugates (A2DCs) with enzymatically cleavable groups
Ref 2	Antibody-Drug Conjugates with Pyrrole-Based KSP Inhibitors as the Payload Class. Angew Chem Int Ed Engl. 2018 Nov 12;57(46):15243-15247. doi: 10.1002/anie.201807619. Epub 2018 Oct 15.
Ref 3	Binder-wirkstoff-konjugate (adcs) und binder-prodrug-konjugate (apdcs) mit enzymatisch spaltbaren gruppen.
Ref 4	Antibody-drug conjugates harboring a kinesin spindle protein inhibitor with immunostimulatory properties. Oncoimmunology. 2022 Feb 9;11(1):2037216. doi: 10.1080/2162402X.2022.2037216. eCollection 2022.
Ref 5	Antibody-Prodrug Conjugates with KSP Inhibitors and Legumain-Mediated Metabolite Formation. Chemistry. 2019 Jun 21;25(35):8208-8213. doi: 10.1002/chem.201900441. Epub 2019 Apr 15.
Ref 6	Antibody drug conjugates with enzymatically cleavable groups
Ref 7	Antibody-drug conjugates cleavable in a tumor microenvironment

Antigen Information

Citation

Visitor Map

Correspondence

Prof. Feng ZHU (zhufeng@zju.edu.cn)

Prof. Xiaowu DONG (dongxw@zju.edu.cn)

Prof. Luo FANG (fangluo@zjcc.org.cn)