Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)
ADC ID
DRG0YQGHS
ADC Name
US20250025567A1 ExL1A2
Synonyms
US20250025567A1 ExL1A2
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Organization
ASTELLAS PHARMA INC.
Drug Status
Investigative
Drug-to-Antibody Ratio
4.02
Structure
Antibody Name
anti-hCLDN6 antibody Ab2
  Antibody Info 
Antigen Name
Claudin-6 (CLDN6)
  Antigen Info 
Payload Name
Undisclosed
Therapeutic Target
Stimulator of interferon genes protein (STING1)
  Target Info 
Linker Name
3-Maleimidopropionic acid linker
  Linker Info 
Conjugate Type
Random conjugation through reduced inter-chain cysteines.
Combination Type
1-{3-[ (3S)-4-[ (4-{[2-amino-4- (pentylamino)-5H-pyrrolo[3,2-d]pyrimidin-5-yl]methyl}-3-methoxyphenyl])methyl]-3- (fluo-romethyl)piperazin-1-yl]-3-oxopropy1}-1H-pyrrole-2,5-dione (trifluoroacetic acid) salt
General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Click To Hide/Show 2 Activity Data Related to This Level
Standard Type Value Units Cell Line Disease Model
The ADC concentration required to produce 10,000 pg/mL TNF-alpha was evaluated. 
> 1000
nM
.
CVCL_1612
Normal
Gastric adenocarcinoma
The ADC concentration required to produce 10,000 pg/mL INF-Gamma was evaluated. 
100- 1000
nM
.
CVCL_1612
Normal
Gastric adenocarcinoma
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
Click To Hide/Show 2 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data The ADC concentration required to produce 10,000 pg/mL TNF-alpha was evaluated. > 1000 nM Positive CLDN6 expression (CLDN6+++/++)
Method Description
ExL1A2 was tested in co-culture system consisting of Human peripheral blood mononuclear cells (PBMCs) and NUGC33 cells, with the concentration range of 5.5 uM to 0.97 uM,TNF-a and INF-y productions were measured.
In Vitro Model Normal; Gastric adenocarcinoma PBMC cells; NUGC3 cells .;CVCL_1612
Experiment 2 Reporting the Activity Date of This ADC [1]
Efficacy Data The ADC concentration required to produce 10,000 pg/mL INF-Gamma was evaluated. 100- 1000 nM Positive CLDN6 expression (CLDN6+++/++)
Method Description
ExL1A2 was tested in co-culture system consisting of Human peripheral blood mononuclear cells (PBMCs) and NUGC33 cells, with the concentration range of 5.5 uM to 0.97 uM,TNF-a and INF-y productions were measured.
In Vitro Model Normal; Gastric adenocarcinoma PBMC cells; NUGC3 cells .;CVCL_1612
References
Ref 1 Antibody-drug complex containing Toll-like receptor 7/8 dual agonist compound