Antigen Information

General Information of This Antigen
Antigen ID
TAR0UDQEU
Antigen Name
Claudin-6 (CLDN6)
Gene Name
CLDN6
Gene ID
9074
Synonym
Skullin
Sequence
MASAGMQILGVVLTLLGWVNGLVSCALPMWKVTAFIGNSIVVAQVVWEGLWMSCVVQSTG
QMQCKVYDSLLALPQDLQAARALCVIALLVALFGLLVYLAGAKCTTCVEEKDSKARLVLT
SGIVFVISGVLTLIPVCWTAHAIIRDFYNPLVAEAQKRELGASLYLGWAASGLLLLGGGL
LCCTCPSGGSQGPSHYMARYSTSAPAISRGPSEYPTKNYV

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Family
Chondroitin N-acetylgalactosaminyltransferase family
Function
Plays a major role in tight junction-specific obliteration of the intercellular space.

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Uniprot Entry
CLD6_HUMAN
HGNC ID
HGNC:2048
KEGG ID
hsa:9074
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
Anti-CLDN (H1L3)- (MSG1-N3)2
 Antibody Info 
ADC Name Payload Target Linker ADC Info
JP7615189B2 ADC42 [1]
JP7615189B2+ADC41+payload
Undisclosed
JP7615189B2+ADC41+Linker
 ADC Info 
JP7615189B2 ADC43 [1]
JP7615189B2+ADC43+payload
Undisclosed
JP7615189B2+ADC41+Linker
 ADC Info 
JP7615189B2 ADC44 [1]
JP7615189B2+ADC44+payload
Undisclosed
JP7615189B2+ADC41+Linker
 ADC Info 
JP7615189B2 ADC45 [1]
JP7615189B2+ADC45+payload
Undisclosed
JP7615189B2+ADC41+Linker
 ADC Info 
JP7615189B2 ADC46 [1]
JP7615189B2+ADC46+payload
Undisclosed
JP7615189B2+ADC41+Linker
 ADC Info 
JP7615189B2 ADC47 [1]
JP7615189B2+ADC47+payload
Undisclosed
JP7615189B2+ADC41+Linker
 ADC Info 
JP7615189B2 ADC48 [1]
JP7615189B2+ADC48+payload
Undisclosed
JP7615189B2+ADC41+Linker
 ADC Info 
JP7615189B2 ADC49 [1]
JP7615189B2+ADC40+payload
Undisclosed
JP7615189B2+ADC41+Linker
 ADC Info 
Anti-CLDN6 (H1L1) - (MSG1-N3)2
 Antibody Info 
ADC Name Payload Target Linker ADC Info
JP7615189B2 ADC40 [1]
JP7615189B2+ADC40+payload
Undisclosed
JP7615189B2+ADC40+Linker
 ADC Info 
Anti-CLDN6 (H2L2)- (MSGI-N3)2
 Antibody Info 
ADC Name Payload Target Linker ADC Info
JP7615189B2 ADC41 [1]
JP7615189B2+ADC41+payload
Undisclosed
JP7615189B2+ADC41+Linker
 ADC Info 
Anti-CLDN6 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
DS-9606a
PBD dimer
Human deoxyribonucleic acid (hDNA)
A cleavable linker
 ADC Info 
AT-03 [2]
TCS132 (AxcynDOT)
Human deoxyribonucleic acid (hDNA)
A cleavable linker
 ADC Info 
QLS5132 [3]
QLS6916
Human deoxyribonucleic acid (hDNA)
A cleavable linker
 ADC Info 
anti-hCLDN6 antibody Ab1
 Antibody Info 
ADC Name Payload Target Linker ADC Info
US20250025567A1 ExL1A1 [4]
5-[ (4-{[ (2S)-2- (fluoromethyl)piperazin-1-yl]methyl}-2-methoxyphenyl)methyl|]-N4-pentyl-5H-pyrrolo[3,2-d]pyrimidine-2,4-diamine
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8)
3-Maleimidopropionic acid linker
 ADC Info 
US20250025567A1 ExL5A1 [4]
US20250025567A1, ExlL5A1, Payload
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8)
Ethylmaleimide linker
 ADC Info 
US20250025567A1 ExL7A1 [4]
US20250025567A1, ExlL7A1, Payload
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8)
3-Maleimidopropionic acid linker
 ADC Info 
US20250025567A1 ExL9A1 [4]
US20250025567A1, ExlL7A1, Payload
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8)
3-Maleimidopropionic acid linker
 ADC Info 
anti-hCLDN6 antibody Ab2
 Antibody Info 
ADC Name Payload Target Linker ADC Info
US20250025567A1 ExL1A2 [4]
Undisclosed
Undisclosed
3-Maleimidopropionic acid linker
 ADC Info 
GB7008-01
 Antibody Info 
ADC Name Payload Target Linker ADC Info
GB7008-01-Val-Cit-MMAE [5]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
IMAB027-Val-Cit-MMAE [6]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
Ixotatug vedotin
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
PLB-002-ab7
 Antibody Info 
ADC Name Payload Target Linker ADC Info
PLB-002 [7]
Eribulin
Microtubule (MT)
A cleavable linker
 ADC Info 
Trastuzumab- (MSG1-N3)2
 Antibody Info 
ADC Name Payload Target Linker ADC Info
JP7615189B2 ADC21 [1]
JP7615189B2+ADC21+payload
Undisclosed
JP7615189B2+ADC21+Linker
 ADC Info 
JP7615189B2 ADC22 [1]
JP7615189B2+ADC22+payload
Undisclosed
JP7615189B2+ADC21+Linker
 ADC Info 
JP7615189B2 ADC23 [1]
JP7615189B2+ADC23+payload
Undisclosed
JP7615189B2+ADC21+Linker
 ADC Info 
JP7615189B2 ADC24 [1]
JP7615189B2+ADC24+payload
Undisclosed
JP7615189B2+ADC24+Linker
 ADC Info 
JP7615189B2 ADC25 [1]
JP7615189B2+ADC23+payload
Undisclosed
JP7615189B2+ADC21+Linker
 ADC Info 
JP7615189B2 ADC26 [1]
JP7615189B2+ADC26+payload
Undisclosed
JP7615189B2+ADC24+Linker
 ADC Info 
JP7615189B2 ADC27 [1]
JP7615189B2+ADC27+payload
Undisclosed
JP7615189B2+ADC27+Linker
 ADC Info 
JP7615189B2 ADC28 [1]
JP7615189B2+ADC28+payload
Undisclosed
JP7615189B2+ADC14+Linker
 ADC Info 
JP7615189B2 ADC29 [1]
JP7615189B2+ADC29+payload
Undisclosed
JP7615189B2+ADC14+Linker
 ADC Info 
JP7615189B2 ADC30 [1]
JP7615189B2+ADC30+payload
Undisclosed
JP7615189B2+ADC14+Linker
 ADC Info 
JP7615189B2 ADC31 [1]
JP7615189B2+ADC31+payload
Undisclosed
JP7615189B2+ADC14+Linker
 ADC Info 
JP7615189B2 ADC32 [1]
JP7615189B2+ADC32+payload
Undisclosed
JP7615189B2+ADC32+Linker
 ADC Info 
JP7615189B2 ADC33 [1]
JP7615189B2+ADC33+payload
Undisclosed
JP7615189B2+ADC32+Linker
 ADC Info 
JP7615189B2 ADC34 [1]
JP7615189B2+ADC34+payload
Undisclosed
JP7615189B2+ADC34+Linker
 ADC Info 
JP7615189B2 ADC35 [1]
JP7615189B2+ADC34+payload
Undisclosed
JP7615189B2+ADC35+Linker
 ADC Info 
JP7615189B2 ADC36 [1]
JP7615189B2+ADC35+payload
Undisclosed
JP7615189B2+ADC21+Linker
 ADC Info 
JP7615189B2 ADC37 [1]
JP7615189B2+ADC34+payload
Undisclosed
JP7615189B2+ADC37+Linker
 ADC Info 
JP7615189B2 ADC38 [1]
JP7615189B2+ADC38+payload
Undisclosed
JP7615189B2+ADC38+Linker
 ADC Info 
JP7615189B2 ADC39 [1]
JP7615189B2+ADC39+payload
Undisclosed
JP7615189B2+ADC39+Linker
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
AT65474 [8]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ADCT-242 [9]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024043319A1 81 [10]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP7615189B2 ADC1 [1]
JP7615189B2+ADC1+payload
Undisclosed
JP7615189B2+ADC1+Linker
 ADC Info 
JP7615189B2 ADC2 [1]
JP7615189B2+ADC2+payload
Undisclosed
JP7615189B2+ADC1+Linker
 ADC Info 
JP7615189B2 ADC3 [1]
JP7615189B2+ADC3+payload
Undisclosed
JP7615189B2+ADC1+Linker
 ADC Info 
JP7615189B2 ADC4 [1]
JP7615189B2+ADC4+payload
Undisclosed
JP7615189B2+ADC1+Linker
 ADC Info 
JP7615189B2 ADC5 [1]
JP7615189B2+ADC5+payload
Undisclosed
JP7615189B2+ADC1+Linker
 ADC Info 
JP7615189B2 ADC6 [1]
JP7615189B2+ADC6+payload
Undisclosed
JP7615189B2+ADC1+Linker
 ADC Info 
JP7615189B2 ADC7 [1]
JP7615189B2+ADC7+payload
Undisclosed
JP7615189B2+ADC1+Linker
 ADC Info 
JP7615189B2 ADC8 [1]
JP7615189B2+ADC8+payload
Undisclosed
JP7615189B2+ADC1+Linker
 ADC Info 
JP7615189B2 ADC9 [1]
JP7615189B2+ADC9+payload
Undisclosed
JP7615189B2+ADC1+Linker
 ADC Info 
JP7615189B2 ADC10 [1]
JP7615189B2+ADC10+payload
Undisclosed
JP7615189B2+ADC10+Linker
 ADC Info 
JP7615189B2 ADC11 [1]
JP7615189B2+ADC11+payload
Undisclosed
JP7615189B2+ADC1+Linker
 ADC Info 
JP7615189B2 ADC12 [1]
JP7615189B2+ADC12+payload
Undisclosed
JP7615189B2+ADC1+Linker
 ADC Info 
JP7615189B2 ADC13 [1]
JP7615189B2+ADC13+payload
Undisclosed
JP7615189B2+ADC13+Linker
 ADC Info 
JP7615189B2 ADC14 [1]
JP7615189B2+ADC14+payload
Undisclosed
JP7615189B2+ADC14+Linker
 ADC Info 
JP7615189B2 ADC15 [1]
JP7615189B2+ADC9+payload
Undisclosed
JP7615189B2+ADC14+Linker
 ADC Info 
JP7615189B2 ADC16 [1]
JP7615189B2+ADC16+payload
Undisclosed
JP7615189B2+ADC14+Linker
 ADC Info 
JP7615189B2 ADC17 [1]
JP7615189B2+ADC16+payload
Undisclosed
JP7615189B2+ADC14+Linker
 ADC Info 
JP7615189B2ADC18 [1]
JP7615189B2+ADC18+payload
Undisclosed
JP7615189B2+ADC14+Linker
 ADC Info 
JP7615189B2 ADC19 [1]
JP7615189B2+ADC19+payload
Undisclosed
JP7615189B2+ADC14+Linker
 ADC Info 
JP7615189B2 ADC20 [1]
Undisclosed
Undisclosed
JP7615189B2+ADC20+Linker
 ADC Info 
References
Ref 1 Antibody-pyrrolobenzodiazepine derivative conjugates
Ref 2 Axcynsis therapeutics product pipeline
Ref 3 QLS5132, a highly selective anti-CLDN6 ADC with broader therapeutic window
Ref 4 Antibody-drug complex containing Toll-like receptor 7/8 dual agonist compound
Ref 5 Introduction to basic information on ADC drug GB-7008-01-vcMMAE.
Ref 6 Preclinical characterization of the safety and antitumor activity of IMAB027-vcMMAE, an anticlaudin 6 antibody-drug conjugate. Cancer Res (2018) 78 (13_Supplement): 1778.
Ref 7 PLB-002 is a novel Claudin 6 antibody-drug conjugate for ovarian cancer and testicular germ cell cancer
Ref 8 AT65474, a highly selective anti-CLDN6 ADC with a proprietary payload
Ref 9 Preclinical investigation of ADCT-242, a novel exatecan-based antibody drug conjugate targeting Claudin-6, as single agent or in combination in ovarian and non-small lung cancer models
Ref 10 Antibody-drug complexes