Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0WXUWV
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| ADC Name |
mBRC-101
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| Synonyms |
MBRC-101
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| Organization |
MBrace (Originator)
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| Drug Status |
Phase 1/2
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| Drug-to-Antibody Ratio |
4
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| Structure |
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| Antibody Name |
Anti-EphA5 mAb
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Antibody Info | ||||
| Antigen Name |
Ephrin type-A receptor 5 (EPHA5)
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Antigen Info | ||||
| Payload Name |
MMAE
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Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
ThioBridge bis-sulfone Val-Cit linker
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Linker Info | ||||
| Conjugate Type |
Reactive Cysteines
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The indication landscape of This ADC(2027 Update)
The clinical trial pipeline of This ADC(2027 Update)
| Indication | Phase 1 | Phase 1/2 | Phase 2 | Phase 2/3 | Phase 3 | New Drug Application | Approved | ||
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| Breast cancer |
1 Trials
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| Cervical cancer |
1 Trials
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| Gastric cancer |
1 Trials
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| Head and neck cancer |
1 Trials
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| Liver cancer |
1 Trials
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| Lung cancer |
1 Trials
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| Oesophageal cancer |
1 Trials
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| Ovarian cancer |
1 Trials
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| Pancreatic cancer |
1 Trials
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| Skin cancer |
1 Trials
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| Unspecific solid tumor |
1 Trials
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