Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)
ADC ID
DRG0WQCQO
ADC Name
Hu47-14-2-A
Synonyms
Hu47-14-2-A
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Organization
JIANGSU HENGRUI MEDICINE CO., LTD.
Drug Status
Investigative
Drug-to-Antibody Ratio
6.6
Structure
Antibody Name
Hu47
  Antibody Info 
Antigen Name
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)
  Antigen Info 
Payload Name
RU2833323C1+Hu63-13-2-A+payload
  Payload Info 
Linker Name
Mc-Gly-Gly-Phe-Gly
  Linker Info 
General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Click To Hide/Show 4 Activity Data Related to This Level
Standard Type Value Units Cell Line Disease Model
Half Maximal inhibitory Concentration (lC50) 
6.58
nM
CVCL_0434
Gastric adenocarcinoma
Half Maximal inhibitory Concentration (lC50) 
10.3
nM
CVCL_1384
Colon adenocarcinoma
Half Maximal inhibitory Concentration (lC50) 
106.3
nM
CVCL_0291
Colon carcinoma
Half Maximal Effective Concentration (EC50) 
4.19
nM
CVCL_0434
Gastric adenocarcinoma
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
Click To Hide/Show 4 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50) 6.58 nM High CEACAM5 expression (CEACAM5 +++)
Method Description
A Cell line test on MKN45
In Vitro Model Gastric adenocarcinoma MKN45 cells CVCL_0434
Experiment 2 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50) 10.3 nM Moderate CEACAM5 expression (CEACAM5++)
Method Description
A Cell line test on LS174T
In Vitro Model Colon adenocarcinoma LS174T cells CVCL_1384
Experiment 3 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50) 106.3 nM Negative CEACAM5 expression (CEACAM5-)
Method Description
A Cell line test on HCT116
In Vitro Model Colon carcinoma HCT116 cells CVCL_0291
Experiment 4 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Effective Concentration (EC50) 4.19 nM High CEACAM5 expression (CEACAM5 +++)
Method Description
A Cell line test on MKN45
In Vitro Model Gastric adenocarcinoma MKN45 cells CVCL_0434
References
Ref 1 Conjugate of anti-CEA antibody and exatecan analog and pharmaceutical uses thereof