Target Information

General Information of This Target

Target ID	PAYTAR0JYZMH
Target Name	CRBN×GSPT1

Full List of The ADC Related to This Target

Phase 1

Click To Hide/Show 1 ADC Related to This Stage

ADC Info	ADC Name	Antibody	Antigen	Payload	Linker	Ref
ADC Info	BMS-986497	OR000283	CD33	SMol006	β-glucuronide linker	[1]

Phase 1 (discontinued)

Click To Hide/Show 1 ADC Related to This Stage

ADC Info	ADC Name	Antibody	Antigen	Payload	Linker	Ref
ADC Info	ORM-5029	Pertuzumab	HER2	SMol006	Mc-Val-Cit-PABC	[2]

References

Ref 1	Abstract 2700: ORM-6151: A first-in-class CD33-antibody enabled GSPT1 degrader for AML
Ref 2	Abstract 3933: ORM-5029: A first-in-class targeted protein degradation therapy using antibody neodegrader conjugate (AnDC) for HER2-expressing breast cancer