Target Information

General Information of This Target (ID: PAYTAR0JYZMH)

Target Name	CRBN×GSPT1

Full List of The ADC Related to This Target

Phase 1

Click To Hide/Show 1 ADC Related to This Stage

ADC Name	Antibody	Antigen	Payload	Linker	ADC Info
BMS-986497 ^[1]	OR000283	Myeloid cell surface antigen CD33 (CD33)	SMol006	β-glucuronide linker	ADC Info

Phase 1 (discontinued)

Click To Hide/Show 1 ADC Related to This Stage

ADC Name	Antibody	Antigen	Payload	Linker	ADC Info
ORM-5029 ^[2]	Pertuzumab	Receptor tyrosine-protein kinase erbB-2 (HER2)	SMol006	Mc-Val-Cit-PABC	ADC Info

References

Ref 1	Abstract 2700: ORM-6151: A first-in-class CD33-antibody enabled GSPT1 degrader for AML
Ref 2	Abstract 3933: ORM-5029: A first-in-class targeted protein degradation therapy using antibody neodegrader conjugate (AnDC) for HER2-expressing breast cancer