Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0SZXVK
|
|||||
|---|---|---|---|---|---|---|
| ADC Name |
PF-08046032
|
|||||
| Synonyms |
PF-08046032
Click to Show/Hide
|
|||||
| Organization |
Pfizer (Top20 MNC) (Originator)
|
|||||
| Drug Status |
Phase 1
|
|||||
| Drug-to-Antibody Ratio |
4
|
|||||
| Structure |
|
|||||
|
|
||||||
| Antibody Name |
A detuned-affinity anti-CD25 mAb
|
Antibody Info | ||||
| Antigen Name |
Interleukin-2 receptor subunit alpha (IL2RA)
|
Antigen Info | ||||
| Payload Name |
MMAE
|
Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
|
Target Info | ||||
| Linker Name |
Mc-Val-Cit-PABC
|
Linker Info | ||||
| Conjugate Type |
Random Cysteines
|
|||||
| Combination Type |
vedotin
|
|||||
The indication landscape of This ADC(2027 Update)
The clinical trial pipeline of This ADC(2027 Update)
| Indication | Phase 1 | Phase 1/2 | Phase 2 | Phase 2/3 | Phase 3 | New Drug Application | Approved | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Diffuse large b-cell lymphoma |
2 Trials
|
|||||||||
| Head and neck cancer |
2 Trials
|
|||||||||
| Hodgkin lymphoma |
2 Trials
|
|||||||||
| Lung cancer |
2 Trials
|
|||||||||
| Mature t-cell lymphoma |
2 Trials
|
|||||||||
| Melanoma |
1 Trials
|
|||||||||
| Unspecific solid tumor |
1 Trials
|