Payload Information

General Information of This Payload
Payload ID
PAY0PCBLR
Name
CN119630431A ADC-51 payload
Synonyms
SCHEMBL27101981; SCHEMBL30781761
   Click to Show/Hide
Structure
Formula
C52H57N9O6
Isosmiles
CN(C=C(C(C=CC1=NC(N2CCC(N3CCC(C)(NCC#CC4=CC=C(OC)C(N(CCC5=O)C(N5)=O)=C4)CC3)CC2)=N6)=CC1=C6[C@](C7=CC=CC=C7)(OC8CC8)CO)C9=C%10NC=C9)C%10=O
InChI
InChI=1S/C52H57N9O6/c1-51(54-23-7-8-34-11-16-44(66-3)43(30-34)61-27-20-45(63)56-50(61)65)21-28-59(29-22-51)37-18-25-60(26-19-37)49-55-42-15-12-35(41-32-58(2)48(64)46-39(41)17-24-53-46)31-40(42)47(57-49)52(33-62,67-38-13-14-38)36-9-5-4-6-10-36/h4-6,9-12,15-17,24,30-32,37-38,53-54,62H,13-14,18-23,25-29,33H2,1-3H3,(H,56,63,65)/t52-/m0/s1
InChIKey
CWIZHMDTDKAALC-MPLRIKRWSA-N
Pharmaceutical Properties
Molecule Weight
904.085
Polar area
170.18
Complexity
2890.845972
xlogp Value
5.8112
Heavy Count
67
Rot Bonds
12
Hbond acc
12
Hbond Donor
4
Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
WO2024043319A1 27 [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50) < 0.015 nM Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++)
Method Description
In vitro cytotoxicity of ADCs in AsPC-1 cells.
In Vitro Model Pancreatic ductal adenocarcinoma AsPC-1 cells CVCL_0152
WO2024043319A1 30 [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50) < 0.015 nM Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++)
Method Description
In vitro cytotoxicity of ADCs in AsPC-1 cells.
In Vitro Model Pancreatic ductal adenocarcinoma AsPC-1 cells CVCL_0152
WO2024043319A1 28 [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50)
0.023 nM
Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++)
Method Description
In vitro cytotoxicity of ADCs in AsPC-1 cells.
In Vitro Model Pancreatic ductal adenocarcinoma AsPC-1 cells CVCL_0152
WO2024043319A1 32 [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50)
0.027 nM
Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++)
Method Description
In vitro cytotoxicity of ADCs in AsPC-1 cells.
In Vitro Model Pancreatic ductal adenocarcinoma AsPC-1 cells CVCL_0152
WO2024043319A1 19 [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50)
0.031 nM
Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++)
Method Description
In vitro cytotoxicity of ADCs in AsPC-1 cells.
In Vitro Model Pancreatic ductal adenocarcinoma AsPC-1 cells CVCL_0152
WO2024043319A1 26 [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50)
0.032 nM
Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++)
Method Description
In vitro cytotoxicity of ADCs in AsPC-1 cells.
In Vitro Model Pancreatic ductal adenocarcinoma AsPC-1 cells CVCL_0152
WO2024043319A1 23 [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50)
0.034 nM
Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++)
Method Description
In vitro cytotoxicity of ADCs in AsPC-1 cells.
In Vitro Model Pancreatic ductal adenocarcinoma AsPC-1 cells CVCL_0152
WO2024043319A1 16 [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50)
0.035 nM
Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++)
Method Description
In vitro cytotoxicity of ADCs in AsPC-1 cells.
In Vitro Model Pancreatic ductal adenocarcinoma AsPC-1 cells CVCL_0152
WO2024043319A1 36 [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50)
0.035 nM
Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++)
Method Description
In vitro cytotoxicity of ADCs in AsPC-1 cells.
In Vitro Model Pancreatic ductal adenocarcinoma AsPC-1 cells CVCL_0152
WO2024043319A1 10 [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50)
0.036 nM
Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++)
Method Description
In vitro cytotoxicity of ADCs in AsPC-1 cells.
In Vitro Model Pancreatic ductal adenocarcinoma AsPC-1 cells CVCL_0152
WO2024043319A1 31 [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50)
0.037 nM
Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++)
Method Description
In vitro cytotoxicity of ADCs in AsPC-1 cells.
In Vitro Model Pancreatic ductal adenocarcinoma AsPC-1 cells CVCL_0152
WO2024043319A1 12 [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50)
0.038 nM
Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++)
Method Description
In vitro cytotoxicity of ADCs in AsPC-1 cells.
In Vitro Model Pancreatic ductal adenocarcinoma AsPC-1 cells CVCL_0152
WO2024043319A1 35 [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50)
0.038 nM
Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++)
Method Description
In vitro cytotoxicity of ADCs in AsPC-1 cells.
In Vitro Model Pancreatic ductal adenocarcinoma AsPC-1 cells CVCL_0152
WO2024043319A1 11 [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50)
0.039 nM
Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++)
Method Description
In vitro cytotoxicity of ADCs in AsPC-1 cells.
In Vitro Model Pancreatic ductal adenocarcinoma AsPC-1 cells CVCL_0152
WO2024043319A1 39 [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50)
0.039 nM
Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++)
Method Description
In vitro cytotoxicity of ADCs in AsPC-1 cells.
In Vitro Model Pancreatic ductal adenocarcinoma AsPC-1 cells CVCL_0152
WO2024043319A1 17 [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50)
0.04 nM
Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++)
Method Description
In vitro cytotoxicity of ADCs in AsPC-1 cells.
In Vitro Model Pancreatic ductal adenocarcinoma AsPC-1 cells CVCL_0152
WO2024043319A1 29 [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50)
0.041 nM
Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++)
Method Description
In vitro cytotoxicity of ADCs in AsPC-1 cells.
In Vitro Model Pancreatic ductal adenocarcinoma AsPC-1 cells CVCL_0152
WO2024043319A1 8 [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50)
0.043 nM
Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++)
Method Description
In vitro cytotoxicity of ADCs in AsPC-1 cells.
In Vitro Model Pancreatic ductal adenocarcinoma AsPC-1 cells CVCL_0152
WO2024043319A1 24 [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50)
0.043 nM
Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++)
Method Description
In vitro cytotoxicity of ADCs in AsPC-1 cells.
In Vitro Model Pancreatic ductal adenocarcinoma AsPC-1 cells CVCL_0152
WO2024043319A1 40 [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50)
0.044 nM
Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++)
Method Description
In vitro cytotoxicity of ADCs in AsPC-1 cells.
In Vitro Model Pancreatic ductal adenocarcinoma AsPC-1 cells CVCL_0152
WO2024043319A1 38 [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50)
0.047 nM
Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++)
Method Description
In vitro cytotoxicity of ADCs in AsPC-1 cells.
In Vitro Model Pancreatic ductal adenocarcinoma AsPC-1 cells CVCL_0152
WO2024043319A1 7 [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50)
0.051 nM
Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++)
Method Description
In vitro cytotoxicity of ADCs in AsPC-1 cells.
In Vitro Model Pancreatic ductal adenocarcinoma AsPC-1 cells CVCL_0152
WO2024043319A1 25 [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50)
0.057 nM
Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++)
Method Description
In vitro cytotoxicity of ADCs in AsPC-1 cells.
In Vitro Model Pancreatic ductal adenocarcinoma AsPC-1 cells CVCL_0152
WO2024043319A1 9 [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50)
0.075 nM
Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++)
Method Description
In vitro cytotoxicity of ADCs in AsPC-1 cells.
In Vitro Model Pancreatic ductal adenocarcinoma AsPC-1 cells CVCL_0152
WO2024043319A1 37 [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50)
0.075 nM
Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++)
Method Description
In vitro cytotoxicity of ADCs in AsPC-1 cells.
In Vitro Model Pancreatic ductal adenocarcinoma AsPC-1 cells CVCL_0152
WO2024043319A1 34 [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50)
0.083 nM
Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++)
Method Description
In vitro cytotoxicity of ADCs in AsPC-1 cells.
In Vitro Model Pancreatic ductal adenocarcinoma AsPC-1 cells CVCL_0152
References
Ref 1 Antibody-drug complexes