Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0SDALC
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| ADC Name |
aU2023279443A1 Example A9
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| Synonyms |
AU2023279443A1 Example A9
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| Organization |
UBE CORPORATION
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| Drug Status |
Investigative
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| Drug-to-Antibody Ratio |
6.7
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| Antibody Name |
Trastuzumab
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Antibody Info | ||||
| Antigen Name |
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
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Antigen Info | ||||
| Payload Name |
U-036
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Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
RU20241285-9-linker
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Linker Info | ||||
| Conjugate Type |
Random conjugation through reduced inter-chain cysteines.
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| Combination Type |
Exemplification A3-9
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ADC-specific functional property(2027 Update)
Payload Release Efficiency
| Incubation Time | 24hr | Release | 98% | Reference |
[1]
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| Description |
Metabolism test using human liver lysosomal fraction. To a reaction composition solution in which human liver lysosome (corresponding to 0.125 mg of protein) was suspended and distilled water (10 uL) was added 1.2 uM test compound (25 uL) dissolved in PBS to prepare a reaction solution. After the reaction solution was incubated at 37 °C for 24 hours, U-036 released from the Example A9 into the reaction solution was quantified by LC-MS/MS.
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| Incubation Time | 24hr | Release | 40% | Reference |
[1]
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| Description |
Metabolism test using human liver Cathepsin B. To human liver Cathepsin B (corresponding to 400 Unit/mL) (5 pL), X10 Catabolic Buffer (10 uL), 2.5 mM Bovine Serum Albumin (5 uL), and distilled water (55 uL) was added 1.2 uM test compound (25 uL) dissolved in PBS to prepare a reaction solution. After the reaction solution was incubated at 37°C for 24 hours, U-036 released from the Example A9 into the reaction solution was quantified by LC-MS/MS.
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