Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0RSTHX
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| ADC Name |
H1L2-Dxd
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| Synonyms |
DS-6000a
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| Organization |
Daiichi Sankyo Company Limited
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| Drug Status |
Investigative
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| Drug-to-Antibody Ratio |
7-8
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| Structure |
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| Antibody Name |
undisclosed
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| Antigen Name |
Cadherin-6 (CDH6)
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Antigen Info | ||||
| Payload Name |
Undisclosed
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| Therapeutic Target |
Stimulator of interferon genes protein (STING1)
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Target Info | ||||
| Linker Name |
CN119255825A H1L2-Dxd Linker
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Linker Info | ||||
| Conjugate Type |
Random conjugation through reduced inter-chain cysteines
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General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | > 100 nM | High C10orf54 expression (C10orf54 +++) | ||
| Method Description |
C1.18 DBM- (C6)-MMAF was tested in OCI/AML3,100-300nm,3days
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| In Vitro Model | Adult acute myelomonocytic leukemia, Acute myelomonocytic leukemia | OCI/AML3 cells | CVCL_1844 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | > 100 nM | High C10orf54 expression (C10orf54 +++) | ||
| Method Description |
C1.18 DBM- (C6)-MMAF was tested in P31/FUJ,100-300nm,3days
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| In Vitro Model | Acute myeloid leukemia, Childhood acute myeloid leukemia | P31/FUJ cells | CVCL_1632 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | > 100 nM | High C10orf54 expression (C10orf54 +++) | ||
| Method Description |
C1.18 DBM- (C6)-MMAF was tested in PL21,100-300nm,3days
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| In Vitro Model | Acute promyelocytic leukemia | PL21 cells | CVCL_2161 | ||