Linker Information
General Information of This Linker
| Linker ID |
LIN0FQTQR
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| Linker Name |
CN119255825A H1L2-Dxd Linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C25H31N5O8
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| Isosmiles |
O=C1C=CC(N1CCCCCC(NCC(NCC(N[C@H](C(NCC(O)=O)=O)CC2=CC=CC=C2)=O)=O)=O)=O
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| InChI |
InChI=1S/C25H31N5O8/c31-19(9-5-2-6-12-30-22(34)10-11-23(30)35)26-14-20(32)27-15-21(33)29-18(25(38)28-16-24(36)37)13-17-7-3-1-4-8-17/h1,3-4,7-8,10-11,18H,2,5-6,9,12-16H2,(H,26,31)(H,27,32)(H,28,38)(H,29,33)(H,36,37)/t18-/m0/s1
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| InChIKey |
DWPLKZYCOGLRPC-SFHVURJKSA-N
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| Pharmaceutical Properties |
Molecule Weight
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529.55
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Polar area
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191.08
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Complexity
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1007.056437
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xlogp Value
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-1.3675
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Heavy Count
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38
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Rot Bonds
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16
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Hbond acc
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7
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Hbond Donor
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5
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
H1L2-Dxd [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | > 100 nM | High C10orf54 expression (C10orf54 +++) | ||
| Method Description |
C1.18 DBM- (C6)-MMAF was tested in OCI/AML3,100-300nm,3days
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| In Vitro Model | Adult acute myelomonocytic leukemia, Acute myelomonocytic leukemia | OCI/AML3 cells | CVCL_1844 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | > 100 nM | High C10orf54 expression (C10orf54 +++) | ||
| Method Description |
C1.18 DBM- (C6)-MMAF was tested in P31/FUJ,100-300nm,3days
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| In Vitro Model | Acute myeloid leukemia, Childhood acute myeloid leukemia | P31/FUJ cells | CVCL_1632 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | > 100 nM | High C10orf54 expression (C10orf54 +++) | ||
| Method Description |
C1.18 DBM- (C6)-MMAF was tested in PL21,100-300nm,3days
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| In Vitro Model | Acute promyelocytic leukemia | PL21 cells | CVCL_2161 | ||