Payload Information
General Information of This Payload
| Payload ID | PAY0LMNCQ |
|||||
|---|---|---|---|---|---|---|
| Name | WO2024043319A1 13 payload |
|||||
| Synonyms |
PAY0437
Click to Show/Hide
|
|||||
| Structure |
|
|||||
| Formula | C49H53N9O6 |
|||||
| Isosmiles | CN(C=C(C1=CC=C2C(C([C@](C3=CC=CC=C3)(O)CO)=NC(N4CCC(N5CCC(C)(NCC#CC6=CC=C(OC)C(N(CCC7=O)C(N7)=O)=C6)CC5)CC4)=N2)=C1)C8=C9NC=C8)C9=O |
|||||
| InChI |
InChI=1S/C49H53N9O6/c1-48(51-21-7-8-32-11-14-41(64-3)40(28-32)58-25-18-42(60)53-47(58)62)19-26-56(27-20-48)35-16-23-57(24-17-35)46-52-39-13-12-33(38-30-55(2)45(61)43-36(38)15-22-50-43)29-37(39)44(54-46)49(63,31-59)34-9-5-4-6-10-34/h4-6,9-15,22,28-30,35,50-51,59,63H,16-21,23-27,31H2,1-3H3,(H,53,60,62)/t49-/m0/s1
|
|||||
| InChIKey |
JFRUIDBHNKCNAU-GGCSAXROSA-N
|
|||||
| Pharmaceutical Properties | Molecule Weight |
864.02 |
Polar area |
181.18 |
||
Complexity |
2786.058696 |
xlogp Value |
4.6245 |
|||
Heavy Count |
64 |
Rot Bonds |
10 |
|||
Hbond acc |
12 |
Hbond Donor |
5 |
|||
Each Antibody-drug Conjugate Related to This Payload
Full Information of The Activity Data of The ADC(s) Related to This Payload
WO2024043319A1 13 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.043 nM
|
Positive CEACAM6_#84.7 expression (CEACAM6_#84.7 +++/++) | ||
| Method Description |
In vitro cytotoxicity of ADCs in AsPC-1 cells.
|
||||
| In Vitro Model | Pancreatic ductal adenocarcinoma | AsPC-1 cells | CVCL_0152 | ||