Antigen Information

General Information of This Antigen
Antigen ID
TAR0OMIUH
Antigen Name
Receptor tyrosine-protein kinase erbB-2 (HER2 ECD2); Receptor tyrosine-protein kinase erbB-2 (HER2 ECD4)
Gene Name
HER2 ECD2; HER2 ECD4
Synonym1
HER2 ECD2
Synonym2
HER2 ECD4
Sequence1
MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNL
ELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLA
LTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQC
AAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSAN
IQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLP
DLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV
PWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQEC
VEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARC
PSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVG
ILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETEL
RKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSP
YVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVR
LVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFT
HQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWM
IDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDA
EEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEG
AGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYV
NQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQ
GGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV

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Sequence2
MPGGCSRGPAAGDGRLRLARLALVLLGWVSSSSPTSSASSFSSSAPFLASAVSAQPPLPD
QCPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAEL
AALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPLVELIL
NHIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQLPSLRHLD
LSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHIRVFLDNNPWVCDC
HMADMVTWLKETEVVQGKDRLTCAYPEKMRNRVLLELNSADLDCDPILPPSLQTSYVFLG
IVLALIGAIFLLVLYLNRKGIKKWMHNIRDACRDHMEGYHYRYEINADPRLTNLSSNSDV

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Family1
Tyr protein family
Family2
Tyr protein kinase family
Function1
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.

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Function2
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.

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Uniprot Entry
ERBB2_HUMAN , ERBB2_HUMAN
HGNC ID
HGNC:3430 , HGNC:3430
KEGG ID
hsa:2064 , hsa:2064
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
Anbenitamab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Anbenitamab repodatecan
DXd
DNA topoisomerase 1 (TOP1)
DBCO-PEG4-Mc-Gly-Gly-Phe-Gly
Anti-HER2 antibody
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
BB-1701
Eribulin
Microtubule (MT)
Mal-PEG2-Val-Cit-PABC
 ADC Info 
TQB2102
2-DDDX-d
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
BAT8010
Exatecan
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
SMP-656
Eribulin
Microtubule (MT)
SuperHydraTM linker
 ADC Info 
BL-M17D1
WA-00
Microtubule (MT)
Undisclosed
 ADC Info 
GB251
MMAE
Microtubule (MT)
BiM-Val-Cit-PABC
 ADC Info 
GQ1007
TLR7/8 agonist
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8)
Stable linker
 ADC Info 
sIBP-A17
DXd
DNA topoisomerase 1 (TOP1)
Mc-VASGFG
 ADC Info 
sYS6045
TOP1 inhibitor
DNA topoisomerase 1 (TOP1)
Undisclosed
Anti-HER2 mAb
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
hMBD-802
Exatecan; ATR inhibitor
ATR+DNA topoisomerase 1 (TOP1)
A cleavable linker
Anvatabart
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Anvatabart opadotin
Amberstatin 269 (AS269)
Microtubule (MT)
Hydroxylamine-PEG4
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Trastuzumab pamirtecan
P1003
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
BAT8001
Batansine
Microtubule (MT)
Maleimido-caproyl
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
DX126-262
Tub114
Microtubule (MT)
Mal-PEG10 based linker
Hertuzumab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Disitamab vedotin
MMAE
Microtubule (MT)
Mc-Val-Cit-PABC
HMA000352
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
hMPL-A251
HM5041609
PI3K; PIKK
A cleavable linker
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
XMT-2056
STING agonist
Stimulator of interferon genes protein (STING1)
Hydrophilic linker of XMT-2056
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Trastuzumab vedotin
MMAE
Microtubule (MT)
Mc-Val-Cit-PABC
 [1]
MEDI-4276
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
MEDI4276
AZ13599185
Microtubule (MT)
Maleimido-caproyl based linker
MHES0488A
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
RG6148
PBD dimer
Human deoxyribonucleic acid (hDNA)
Cleavable disulfide linker
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
NJH395
TLR7 agonist
Toll-like receptor 7 (TLR7)
A non-cleavable linker
Pertuzumab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
SHR-4602
ER300
Microtubule (MT)
Stable enzyme-cleavable linker
 ADC Info 
Pertuzumab zuvotolimod
Zuvotolimod
Toll-like receptor 8 (TLR8)
Mc-Val-Cit-PABC
 ADC Info 
ORM-5029
SMol006
CRBN×GSPT1
Mc-Val-Cit-PABC
 [2]
 ADC Info 
ADC2122
Duostatin 5
Microtubule (MT)
Pip-Val-Cit linker
 [3]
Trastuzumab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
caxmotabart entudotin
MMAF
Microtubule (MT)
β-glucuronide linker
 ADC Info 
cAN016
Exatecan; MMAE
DNA topoisomerase 1 (TOP1)+Microtubule (MT)
Undisclosed
 ADC Info 
T-VDXd
DXd
DNA topoisomerase 1 (TOP1)
Mc-Val-Ala
 ADC Info 
Trastuzumab rezetecan
SHR9265
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 [4]
 ADC Info 
Trastuzumab deruxtecan
DXd
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 [5]
 ADC Info 
Trastuzumab emtansine
DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 [6]
 ADC Info 
Trastuzumab envedotin
MMAE
Microtubule (MT)
NH2-PEG3-Val-Cit-PABC
 ADC Info 
Trastuzumab duocarmazine
Seco-DUBA
Human deoxyribonucleic acid (hDNA)
Mal-PEG2-Val-Cit-PABA-Cyclization Spacer
 ADC Info 
Trastuzumab bultecan
NT1
DNA topoisomerase 1 (TOP1)
PODS-CHX-A"-DTPA
 ADC Info 
Trastuzumab brengitecan
Ed-04
DNA topoisomerase 1 (TOP1)
Gly-Mal-Gly-Gly-Phe-Gly
 ADC Info 
FDA022
DXd
DNA topoisomerase 1 (TOP1)
Mc-Val-Ala-PABC double self-immolative linker
 [7]
 ADC Info 
Trastuzumab imbotolimod
T785
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8)
BG based linker
 [8]
 ADC Info 
Trastuzumab botidotin
Duostatin 5
Microtubule (MT)
K-lock-Val-Cit-PABC
 [9]
 ADC Info 
nC18
AF-HEA
Microtubule (MT)
PHF polymer linker
Trastuzumab variant
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
GQ1005
DXd
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly (ring-opening derivative)
 ADC Info 
GQ1001
DM1
Microtubule (MT)
K'-MCC'
 ADC Info 
ALT-P7
MMAE
Microtubule (MT)
Val-Cit dipeptide linker
 ADC Info 
ADCT-502
SG3199 (SC-DR002)
Human deoxyribonucleic acid (hDNA)
Mal-PEG8-Val-Ala-PABC
Trastuzumab-(κK183C+K290C)
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
PF-06804103
Auristatin 0101 (Aur0101)
Microtubule (MT)
Mc-Val-Cit-PABC
Trastuzumab/Pertuzumab biparatopic bsAb
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
KM501
MMAE
Microtubule (MT)
Undisclosed
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
XMT-1522
AF-HPA
Microtubule (MT)
Fleximer polymer
Zanidatamab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Zanidatamab zovodotin
ZD02044
Microtubule (MT)
Mc-PEG3-Val-Cit
 ADC Info 
ZW-33
Undisclosed
Undisclosed
Undisclosed
 [10]
Undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
JY201
Undisclosed
Undisclosed
Undisclosed
 [11]
References
Ref 1 Introduction to basic information on ADC drug trastuzumab vedotin.
Ref 2 Abstract 3933: ORM-5029: A first-in-class targeted protein degradation therapy using antibody neodegrader conjugate (AnDC) for HER2-expressing breast cancer
Ref 3 Introduction to basic information on ADC drug ZV203; 6 Jan 2020.
Ref 4 Introduction to basic information on ADC drug Trastuzumab rezetecan.
Ref 5 Trastuzumab Deruxtecan in Previously Treated HER2-Low Advanced Breast Cancer
Ref 6 Trastuzumab emtansine: first global approval
Ref 7 Spotlight on Trastuzumab Deruxtecan (DS-8201,T-DXd) for HER2 Mutation Positive Non-Small Cell Lung Cancer
Ref 8 Introduction to basic information on ADC drug trastuzumab imbotolimod.
Ref 9 Introduction to basic information on ADC drug trastuzumab botidotin.
Ref 10 Zymeworks biotechnology company announcement; 2016
Ref 11 A novel pegylated bispecific antibody-drug conjugate (P-BsADC) targeting Her2+ cancers with improved efficacy and therapeutic window. Cancer Res (2023) 83 (7_Supplement): 4000.