Antigen ID	TAR0OMIUH
Antigen Name	Receptor tyrosine-protein kinase erbB-2 (HER2 ECD2); Receptor tyrosine-protein kinase erbB-2 (HER2 ECD4)
Gene Name	HER2 ECD2; HER2 ECD4
Gene ID	2064 , 2064
Synonym1	HER2 ECD2
Synonym2	HER2 ECD4
Sequence1	MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNL ELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG DPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLA LTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQC AAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSAN IQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLP DLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTV PWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQEC VEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARC PSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVG ILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETEL RKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSP YVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVR LVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFT HQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWM IDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDA EEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEG AGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYV NQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQ GGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV     Click to Show/Hide
Sequence2	MPGGCSRGPAAGDGRLRLARLALVLLGWVSSSSPTSSASSFSSSAPFLASAVSAQPPLPD QCPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAEL AALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPLVELIL NHIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQLPSLRHLD LSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHIRVFLDNNPWVCDC HMADMVTWLKETEVVQGKDRLTCAYPEKMRNRVLLELNSADLDCDPILPPSLQTSYVFLG IVLALIGAIFLLVLYLNRKGIKKWMHNIRDACRDHMEGYHYRYEINADPRLTNLSSNSDV     Click to Show/Hide
Family1	Tyr protein family
Family2	Tyr protein kinase family
Function1	Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.     Click to Show/Hide
Function2	Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.     Click to Show/Hide
Uniprot Entry	ERBB2_HUMAN , ERBB2_HUMAN
HGNC ID	HGNC:3430 , HGNC:3430
KEGG ID	hsa:2064 , hsa:2064

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	MEDI-4276	AZ13599185	Microtubule (MT)	Maleimido-caproyl based linker	[1]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Zanidatamab zovodotin	ZD02044	Microtubule (MT)	Mc-PEG3-Val-Cit	[2]
ADC Info	ZW-33	Undisclosed	Undisclosed	Undisclosed	[3]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	JSKN-003	Undisclosed	Undisclosed	Undisclosed	[4]
ADC Info	KM501	Undisclosed	Undisclosed	Undisclosed	[5]
ADC Info	TQB2102	Topoisomerase I inhibitor	DNA topoisomerase 1 (TOP1)	Enzyme-cleavable linker	[6]
ADC Info	JY201	Undisclosed	Undisclosed	Undisclosed	[7]

Differential expression pattern of antigen in diseases
The Studied Tissue	Gingival
The Specific Disease	Bacterial infection of gingival
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.012604643; Fold-change: -0.227313462; Z-score: -0.343912121
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Differential expression pattern of antigen in diseases
The Studied Tissue	Brainstem
The Specific Disease	Glioma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.198499823; Fold-change: 0.206253875; Z-score: 1.788174987
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The Studied Tissue	White matter
The Specific Disease	Glioma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.205668842; Fold-change: -0.145158484; Z-score: -0.935526231
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The Studied Tissue	Brainstem
The Specific Disease	Neuroectodermal tumor
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.010609917; Fold-change: 0.220914299; Z-score: 0.586649079
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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The Studied Tissue	Nervous
The Specific Disease	Brain cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.000474019; Fold-change: -0.143646903; Z-score: -0.35944008
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Polycythemia vera
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.239499347; Fold-change: -0.01603947; Z-score: -0.077605035
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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The Studied Tissue	Whole blood
The Specific Disease	Myelofibrosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.328573514; Fold-change: 0.125386027; Z-score: 0.624530572
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Bone marrow
The Specific Disease	Myelodysplastic syndromes
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.876154929; Fold-change: -0.001779038; Z-score: -0.011801104
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.016265287; Fold-change: -0.192996315; Z-score: -2.408343389
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Tonsil
The Specific Disease	Lymphoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.336092708; Fold-change: -0.161654757; Z-score: -0.815441813
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Differential expression pattern of antigen in diseases
The Studied Tissue	Gastric
The Specific Disease	Gastric cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.002782765; Fold-change: 0.585165915; Z-score: 4.114824985
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 1.49E-08; Fold-change: 0.204756047; Z-score: 0.891446921
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Colon
The Specific Disease	Colon cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 2.99E-17; Fold-change: -0.616192168; Z-score: -0.880827727
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.780532435; Fold-change: 0.108718842; Z-score: 0.155182797
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Pancreas
The Specific Disease	Pancreatic cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.302298466; Fold-change: 0.069838359; Z-score: 0.150669986
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.782977459; Fold-change: -0.164975563; Z-score: -0.417006613
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Liver
The Specific Disease	Liver cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.151225689; Fold-change: -0.073324858; Z-score: -0.157294246
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.589664963; Fold-change: -0.014761025; Z-score: -0.042519418
The Expression Level of Disease Section Compare with the Other Disease Section	p-value: 0.790092503; Fold-change: -0.187685505; Z-score: -0.549772705
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Lung
The Specific Disease	Lung cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.000713882; Fold-change: -0.126046922; Z-score: -0.191222969
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.00351809; Fold-change: -0.110186279; Z-score: -0.139814236
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Skin
The Specific Disease	Melanoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.084824536; Fold-change: -0.263316526; Z-score: -0.576627257
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Differential expression pattern of antigen in diseases
The Studied Tissue	Muscle
The Specific Disease	Sarcoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 4.42E-31; Fold-change: -0.276885656; Z-score: -0.852405448
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.259415131; Fold-change: -0.443169741; Z-score: -1.219076625
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Breast
The Specific Disease	Breast cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 3.50E-77; Fold-change: 0.490641074; Z-score: 1.120664442
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 6.69E-13; Fold-change: 0.354032542; Z-score: 0.624640369
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Ovarian
The Specific Disease	Ovarian cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.000490484; Fold-change: 0.452221886; Z-score: 1.023085171
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.230081828; Fold-change: 0.231462076; Z-score: 0.282151742
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Cervical
The Specific Disease	Cervical cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.345734004; Fold-change: -0.049608938; Z-score: -0.166248044
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Differential expression pattern of antigen in diseases
The Studied Tissue	Endometrium
The Specific Disease	Uterine cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.001385853; Fold-change: 0.067334425; Z-score: 0.152081835
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.354861587; Fold-change: -0.327056014; Z-score: -0.929317632
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Prostate
The Specific Disease	Prostate cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.3644208; Fold-change: -0.229524506; Z-score: -0.380870565
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Differential expression pattern of antigen in diseases
The Studied Tissue	Bladder
The Specific Disease	Bladder cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.005674059; Fold-change: -1.257324423; Z-score: -2.049440451
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Differential expression pattern of antigen in diseases
The Studied Tissue	Uvea
The Specific Disease	Retinoblastoma tumor
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.002329625; Fold-change: -0.210164449; Z-score: -1.148894756
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Differential expression pattern of antigen in diseases
The Studied Tissue	Thyroid
The Specific Disease	Thyroid cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.015374496; Fold-change: -0.319937123; Z-score: -0.422489008
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.001631218; Fold-change: 0.076546714; Z-score: 0.128533682
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Adrenal cortex
The Specific Disease	Adrenocortical carcinoma
The Expression Level of Disease Section Compare with the Other Disease Section	p-value: 0.415860724; Fold-change: -0.202615461; Z-score: -0.567346037
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Differential expression pattern of antigen in diseases
The Studied Tissue	Head and neck
The Specific Disease	Head and neck cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 3.48E-14; Fold-change: -0.647032029; Z-score: -0.778337569
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Differential expression pattern of antigen in diseases
The Studied Tissue	Pituitary
The Specific Disease	Pituitary gonadotrope tumor
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.177027061; Fold-change: 0.440620349; Z-score: 1.078664346
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The Studied Tissue	Pituitary
The Specific Disease	Pituitary cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.011812526; Fold-change: 0.402855648; Z-score: 1.136818895
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Thrombocytopenia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.164692605; Fold-change: 0.306015177; Z-score: 2.917723025
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Lupus erythematosus
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.160823912; Fold-change: -0.041599592; Z-score: -0.10423713
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Differential expression pattern of antigen in diseases
The Studied Tissue	Peripheral monocyte
The Specific Disease	Autoimmune uveitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.003990889; Fold-change: -0.212237911; Z-score: -1.02247083
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Familial hypercholesterolemia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.729031358; Fold-change: -0.002339739; Z-score: -0.008971821
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Superior temporal cortex
The Specific Disease	Schizophrenia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.590381771; Fold-change: 0.076709251; Z-score: 0.633074754
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Spinal cord
The Specific Disease	Multiple sclerosis
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.339474391; Fold-change: -0.058653767; Z-score: -0.163399879
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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The Studied Tissue	Plasmacytoid dendritic cells
The Specific Disease	Multiple sclerosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.231347716; Fold-change: 0.455635147; Z-score: 1.059625839
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Peritumoral cortex
The Specific Disease	Epilepsy
The Expression Level of Disease Section Compare with the Other Disease Section	p-value: 0.140242702; Fold-change: -0.577465457; Z-score: -2.115352885
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Cardioembolic Stroke
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.290174239; Fold-change: -0.022015206; Z-score: -0.118569253
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The Studied Tissue	Peripheral blood
The Specific Disease	Ischemic stroke
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.345010718; Fold-change: 0.091438346; Z-score: 0.447284726
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	White matter
The Specific Disease	HIV
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.083904363; Fold-change: -0.102806679; Z-score: -0.601202519
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Influenza
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.570012539; Fold-change: 0.014892846; Z-score: 0.06072158
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Chronic hepatitis C
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.33670919; Fold-change: -0.113133125; Z-score: -0.786218208
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Sepsis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.571000136; Fold-change: 0.019826642; Z-score: 0.070614896
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Septic shock
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.08996159; Fold-change: -0.066621954; Z-score: -0.207458618
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Peripheral blood
The Specific Disease	Pediatric respiratory syncytial virus infection
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.164764309; Fold-change: -0.016702498; Z-score: -0.100450506
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Peripheral blood
The Specific Disease	Essential hypertension
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.404421238; Fold-change: -0.076886403; Z-score: -4.941160538
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Peripheral blood
The Specific Disease	Myocardial infarction
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.051581685; Fold-change: 0.23189577; Z-score: 0.594795506
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Differential expression pattern of antigen in diseases
The Studied Tissue	Peripheral blood
The Specific Disease	Coronary artery disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.179643487; Fold-change: -0.246267417; Z-score: -1.468327955
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Differential expression pattern of antigen in diseases
The Studied Tissue	Calcified aortic valve
The Specific Disease	Aortic stenosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.222126141; Fold-change: 0.294382577; Z-score: 0.893994387
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Differential expression pattern of antigen in diseases
The Studied Tissue	Peripheral blood
The Specific Disease	Arteriosclerosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.885425763; Fold-change: 0.03950334; Z-score: 0.182468621
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Differential expression pattern of antigen in diseases
The Studied Tissue	Intracranial artery
The Specific Disease	Aneurysm
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.099496449; Fold-change: -0.107553045; Z-score: -0.262160942
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Differential expression pattern of antigen in diseases
The Studied Tissue	Peripheral blood
The Specific Disease	Immunodeficiency
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.033956855; Fold-change: 0.187194317; Z-score: 1.523728854
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Differential expression pattern of antigen in diseases
The Studied Tissue	Hyperplastic tonsil
The Specific Disease	Apnea
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.037096291; Fold-change: -0.25612559; Z-score: -1.968075476
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Differential expression pattern of antigen in diseases
The Studied Tissue	Peripheral blood
The Specific Disease	Olive pollen allergy
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.086119151; Fold-change: 0.117471138; Z-score: 1.381634816
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Differential expression pattern of antigen in diseases
The Studied Tissue	Sinus mucosa
The Specific Disease	Chronic rhinosinusitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.316251629; Fold-change: 0.09873195; Z-score: 0.282647993
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Differential expression pattern of antigen in diseases
The Studied Tissue	Lung
The Specific Disease	Chronic obstructive pulmonary disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.513249565; Fold-change: -0.028829707; Z-score: -0.087820065
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The Studied Tissue	Small airway epithelium
The Specific Disease	Chronic obstructive pulmonary disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.007670236; Fold-change: -0.499952426; Z-score: -0.662223305
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Differential expression pattern of antigen in diseases
The Studied Tissue	Nasal and bronchial airway
The Specific Disease	Asthma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 5.59E-07; Fold-change: -0.283948459; Z-score: -0.222916785
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Differential expression pattern of antigen in diseases
The Studied Tissue	Nasal Epithelium
The Specific Disease	Human rhinovirus infection
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.979233674; Fold-change: -0.036684358; Z-score: -0.105191898
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Differential expression pattern of antigen in diseases
The Studied Tissue	Lung
The Specific Disease	Idiopathic pulmonary fibrosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.356082728; Fold-change: 0.057857538; Z-score: 0.135520535
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Differential expression pattern of antigen in diseases
The Studied Tissue	Gingival
The Specific Disease	Periodontal disease
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.012251837; Fold-change: -0.324126129; Z-score: -0.476765602
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Differential expression pattern of antigen in diseases
The Studied Tissue	Gastric antrum
The Specific Disease	Eosinophilic gastritis
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.095313105; Fold-change: 0.247413617; Z-score: 1.360766367
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Differential expression pattern of antigen in diseases
The Studied Tissue	Liver
The Specific Disease	Liver failure
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.017481405; Fold-change: -0.298951991; Z-score: -1.220916592
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Differential expression pattern of antigen in diseases
The Studied Tissue	Colon mucosal
The Specific Disease	Ulcerative colitis
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.742423766; Fold-change: -0.058447298; Z-score: -0.234895268
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Differential expression pattern of antigen in diseases
The Studied Tissue	Rectal colon
The Specific Disease	Irritable bowel syndrome
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.178049459; Fold-change: -0.06551847; Z-score: -0.255841339
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Differential expression pattern of antigen in diseases
The Studied Tissue	Skin
The Specific Disease	Atopic dermatitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.080307916; Fold-change: -0.132912034; Z-score: -0.685778056
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Differential expression pattern of antigen in diseases
The Studied Tissue	Skin
The Specific Disease	Psoriasis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.245279233; Fold-change: -0.172649165; Z-score: -0.302502826
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 1.89E-41; Fold-change: 0.537445296; Z-score: 2.230434432
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Differential expression pattern of antigen in diseases
The Studied Tissue	Skin
The Specific Disease	Vitiligo
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.354648452; Fold-change: 0.093244905; Z-score: 0.516508092
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Differential expression pattern of antigen in diseases
The Studied Tissue	Skin from scalp
The Specific Disease	Alopecia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.145406491; Fold-change: 0.060466136; Z-score: 0.229385077
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Differential expression pattern of antigen in diseases
The Studied Tissue	Skin
The Specific Disease	Sensitive skin
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.49598425; Fold-change: 0.317323593; Z-score: 0.581470041
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Differential expression pattern of antigen in diseases
The Studied Tissue	Synovial
The Specific Disease	Osteoarthritis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.596294683; Fold-change: 0.00074721; Z-score: 0.002162212
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Differential expression pattern of antigen in diseases
The Studied Tissue	Peripheral blood
The Specific Disease	Arthropathy
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.648891763; Fold-change: -0.016919758; Z-score: -0.07783617
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Differential expression pattern of antigen in diseases
The Studied Tissue	Peripheral blood
The Specific Disease	Arthritis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.343640269; Fold-change: 0.001201018; Z-score: 0.004816102
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Differential expression pattern of antigen in diseases
The Studied Tissue	Synovial
The Specific Disease	Rheumatoid arthritis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.246599282; Fold-change: 0.175239639; Z-score: 0.34416949
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Differential expression pattern of antigen in diseases
The Studied Tissue	Pheripheral blood
The Specific Disease	Ankylosing spondylitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.175614566; Fold-change: 0.113731949; Z-score: 0.480934006
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Differential expression pattern of antigen in diseases
The Studied Tissue	Bone marrow
The Specific Disease	Osteoporosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.040103439; Fold-change: 0.880556385; Z-score: 4.944408728
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Differential expression pattern of antigen in diseases
The Studied Tissue	Endometrium
The Specific Disease	Endometriosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.888712642; Fold-change: -0.093771761; Z-score: -0.25632236
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Differential expression pattern of antigen in diseases
The Studied Tissue	Bladder
The Specific Disease	Interstitial cystitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.001496637; Fold-change: -1.138266278; Z-score: -2.988495247
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Differential expression pattern of antigen in diseases
The Studied Tissue	Myometrium
The Specific Disease	Preterm birth
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.710402149; Fold-change: -0.05864976; Z-score: -0.66030011
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Differential expression pattern of antigen in diseases
The Studied Tissue	Bone marrow
The Specific Disease	Acute myelocytic leukemia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.114727383; Fold-change: -0.048984373; Z-score: -0.251540805
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Differential expression pattern of antigen in diseases
The Studied Tissue	Bone marrow
The Specific Disease	Myeloma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.021335399; Fold-change: 0.095198056; Z-score: 0.629065446
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The Studied Tissue	Peripheral blood
The Specific Disease	Myeloma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.350893053; Fold-change: 0.086227385; Z-score: 0.462021531
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Differential expression pattern of antigen in diseases
The Studied Tissue	Oral
The Specific Disease	Oral cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.015079995; Fold-change: -0.213915921; Z-score: -0.382167512
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 4.78E-09; Fold-change: -0.716067055; Z-score: -0.786617541
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Esophagus
The Specific Disease	Esophagal cancer
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.740405247; Fold-change: -0.275644435; Z-score: -0.514688212
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Differential expression pattern of antigen in diseases
The Studied Tissue	Rectal colon
The Specific Disease	Rectal cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.957525087; Fold-change: -0.117135726; Z-score: -0.225945024
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 1.05E-05; Fold-change: -1.049229149; Z-score: -3.975480307
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Differential expression pattern of antigen in diseases
The Studied Tissue	Skin
The Specific Disease	Skin cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 4.76E-07; Fold-change: -0.485984665; Z-score: -0.748907119
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 1.11E-14; Fold-change: 0.232655645; Z-score: 0.637166891
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Differential expression pattern of antigen in diseases
The Studied Tissue	Kidney
The Specific Disease	Renal cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.292109361; Fold-change: -0.24493717; Z-score: -0.235064848
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 2.68E-15; Fold-change: -0.803082274; Z-score: -1.443359315
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Differential expression pattern of antigen in diseases
The Studied Tissue	Urothelium
The Specific Disease	Ureter cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.931225005; Fold-change: 0.052255676; Z-score: 0.241930943
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Differential expression pattern of antigen in diseases
The Studied Tissue	Adipose
The Specific Disease	Simpson golabi behmel syndrome
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.899369522; Fold-change: -0.100631075; Z-score: -0.675234335
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Differential expression pattern of antigen in diseases
The Studied Tissue	Perituberal
The Specific Disease	Tuberous sclerosis complex
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.146893491; Fold-change: -0.103328516; Z-score: -0.998804448
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Differential expression pattern of antigen in diseases
The Studied Tissue	Bone marrow
The Specific Disease	Anemia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.821558408; Fold-change: 0.112263687; Z-score: 0.543197774
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Differential expression pattern of antigen in diseases
The Studied Tissue	Peripheral blood
The Specific Disease	Sickle cell disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.279092273; Fold-change: 0.212385394; Z-score: 0.715113871
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Thrombocythemia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.54298711; Fold-change: -0.10208841; Z-score: -0.524650255
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Scleroderma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.043075833; Fold-change: 0.191472642; Z-score: 0.883395266
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Differential expression pattern of antigen in diseases
The Studied Tissue	Salivary gland
The Specific Disease	Sjogren syndrome
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.472694164; Fold-change: -0.305825893; Z-score: -1.034130527
The Expression Level of Disease Section Compare with the Adjacent Tissue	p-value: 0.035986035; Fold-change: -0.263974907; Z-score: -1.937527694
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Differential expression pattern of antigen in diseases
The Studied Tissue	Peripheral blood
The Specific Disease	Behcet disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.743109111; Fold-change: 0.129191687; Z-score: 0.49013054
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Autosomal dominant monocytopenia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.581617339; Fold-change: -0.080421466; Z-score: -0.364055736
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Differential expression pattern of antigen in diseases
The Studied Tissue	Liver
The Specific Disease	Type 2 diabetes
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.087601114; Fold-change: -0.165683016; Z-score: -0.989682647
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Differential expression pattern of antigen in diseases
The Studied Tissue	Vastus lateralis muscle
The Specific Disease	Polycystic ovary syndrome
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.124863857; Fold-change: -0.16439822; Z-score: -0.938655765
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Differential expression pattern of antigen in diseases
The Studied Tissue	Subcutaneous Adipose
The Specific Disease	Obesity
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.084778678; Fold-change: -0.122947928; Z-score: -0.787037488
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Differential expression pattern of antigen in diseases
The Studied Tissue	Biceps muscle
The Specific Disease	Pompe disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.917500139; Fold-change: -0.003189095; Z-score: -0.024864192
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Batten disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.977461639; Fold-change: 0.025667446; Z-score: 0.153646914
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Autism
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.017930814; Fold-change: -0.115092535; Z-score: -0.528873069
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Anxiety disorder
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.028470494; Fold-change: 0.051639545; Z-score: 0.251367933
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Differential expression pattern of antigen in diseases
The Studied Tissue	Substantia nigra
The Specific Disease	Parkinson disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.470919115; Fold-change: -0.088008934; Z-score: -0.243685685
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Huntington disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.243429319; Fold-change: 0.115488831; Z-score: 0.793933744
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Differential expression pattern of antigen in diseases
The Studied Tissue	Entorhinal cortex
The Specific Disease	Alzheimer disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.606874505; Fold-change: -0.03918006; Z-score: -0.140924602
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
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Differential expression pattern of antigen in diseases
The Studied Tissue	Whole blood
The Specific Disease	Seizure
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.628096184; Fold-change: 0.137136895; Z-score: 0.534471432
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
Download Antigen expression data of patients in the disease section of the tissue Download Antigen expression data in the tissue of healthy individual

Differential expression pattern of antigen in diseases
The Studied Tissue	Skin
The Specific Disease	Lateral sclerosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.301723855; Fold-change: -0.165174188; Z-score: -0.477732012
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
Download Antigen expression data of patients in the disease section of the tissue Download Antigen expression data in the tissue of healthy individual
The Studied Tissue	Cervical spinal cord
The Specific Disease	Lateral sclerosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.683230296; Fold-change: 0.004772728; Z-score: 0.034888825
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
Download Antigen expression data of patients in the disease section of the tissue Download Antigen expression data in the tissue of healthy individual

Differential expression pattern of antigen in diseases
The Studied Tissue	Muscle
The Specific Disease	Muscular atrophy
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.019006642; Fold-change: -0.251477117; Z-score: -0.966091571
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
Download Antigen expression data of patients in the disease section of the tissue Download Antigen expression data in the tissue of healthy individual

Differential expression pattern of antigen in diseases
The Studied Tissue	Muscle
The Specific Disease	Myopathy
The Expression Level of Disease Section Compare with the Healthy Individual Tissue	p-value: 0.356468651; Fold-change: -0.119099861; Z-score: -0.303362323
Disease-specific Antigen Abundances		Click to View the Clearer Original Diagram
Download Antigen expression data of patients in the disease section of the tissue Download Antigen expression data in the tissue of healthy individual

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Ref 7	A novel pegylated bispecific antibody-drug conjugate (P-BsADC) targeting Her2+ cancers with improved efficacy and therapeutic window. Cancer Res (2023) 83 (7_Supplement): 4000.