Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0PTISV
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| ADC Name |
Hu67-14-2-A (1)
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| Synonyms |
Hu67-14-2-A
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| Organization |
JIANGSU HENGRUI MEDICINE CO., LTD.
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| Drug Status |
Investigative
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| Drug-to-Antibody Ratio |
6.41
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| Structure |
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| Antibody Name |
Hu67
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Antibody Info | ||||
| Antigen Name |
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)
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Antigen Info | ||||
| Payload Name |
RU2833323C1+Hu63-13-2-A+payload
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Payload Info | ||||
| Linker Name |
Mc-Gly-Gly-Phe-Gly
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Linker Info | ||||
General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | 3.331 nM | High CEACAM5 expression (CEACAM5 +++) | ||
| Method Description |
A Cell line test on MKN45
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| In Vitro Model | Gastric adenocarcinoma | MKN45 cells | CVCL_0434 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | 9.236 nM | Moderate CEACAM5 expression (CEACAM5++) | ||
| Method Description |
A Cell line test on LS174T
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| In Vitro Model | Colon adenocarcinoma | LS174T cells | CVCL_1384 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | 71.83 nM | Negative CEACAM5 expression (CEACAM5-) | ||
| Method Description |
A Cell line test on HCT116
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| In Vitro Model | Colon carcinoma | HCT116 cells | CVCL_0291 | ||