Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)
ADC ID
DRG0OUAMY
ADC Name
cN112638426B ADC1
Synonyms
ADC1
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Organization
NATURAL MEDICINE INST OF ZHEJIANG YANGSHENGTANG
Drug Status
Investigative
Structure
Antibody Name
mil40
  Antibody Info 
Antigen Name
Undisclosed
Payload Name
Tubulin inhibitor B
  Payload Info 
Therapeutic Target
Microtubule (MT)
  Target Info 
Linker Name
CN112638426B +ADC1+Linker
  Linker Info 
Conjugate Type
Random conjugation through reduced inter-chain cysteines
General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Click To Hide/Show 5 Activity Data Related to This Level
Standard Type Value Units Cell Line Disease Model
Half Maximal inhibitory Concentration (lC50) 
0.04
nM
CVCL_1259
Breast ductal carcinoma
Half Maximal inhibitory Concentration (lC50) 
0.43
nM
CVCL_1603
Gastric tubular adenocarcinoma
Half Maximal inhibitory Concentration (lC50) 
0.63
nM
CVCL_0179
Invasive breast carcinoma
Half Maximal inhibitory Concentration (lC50) 
194.24
nM
CVCL_0419
Breast adenocarcinoma
Half Maximal inhibitory Concentration (lC50) 
204.88
nM
CVCL_0031
Invasive breast carcinoma
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
Click To Hide/Show 5 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50)
0.04 nM
Method Description
A Cell line test on HCC1954
In Vitro Model Breast ductal carcinoma HCC1954 cells CVCL_1259
Experiment 2 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50)
0.43 nM
Method Description
A Cell line test on NCI-N87
In Vitro Model Gastric tubular adenocarcinoma NCI-N87 cells CVCL_1603
Experiment 3 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50)
0.63 nM
Method Description
A Cell line test on BT-474
In Vitro Model Invasive breast carcinoma BT-474 cells CVCL_0179
Experiment 4 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50)
194.24 nM
Method Description
A Cell line test on MDA-MB-468
In Vitro Model Breast adenocarcinoma MDA-MB-468 cells CVCL_0419
Experiment 5 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50)
204.88 nM
Method Description
A Cell line test on MCF-7
In Vitro Model Invasive breast carcinoma MCF-7 cells CVCL_0031
References
Ref 1 Nitroaryl-based linkers, antibody-drug conjugates comprising the linkers and uses thereof