Linker Information
General Information of This Linker
| Linker ID |
LIN0EJTLN
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| Linker Name |
CN112638426B +ADC1+Linker
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| Linker Type |
Unclear
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| Antibody-Linker Relation |
Unclear
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| Structure |
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| Formula |
C20H24N4O7
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| Isosmiles |
O=C(NCCNC(CCCCCN1C(C=CC1=O)=O)=O)C2=C([N+]([O-])=O)C=CC(CO)=C2
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| InChI |
InChI=1S/C20H24N4O7/c25-13-14-5-6-16(24(30)31)15(12-14)20(29)22-10-9-21-17(26)4-2-1-3-11-23-18(27)7-8-19(23)28/h5-8,12,25H,1-4,9-11,13H2,(H,21,26)(H,22,29)
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| InChIKey |
GTYVEAPWGFFSLS-UHFFFAOYSA-N
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| Pharmaceutical Properties |
Molecule Weight
|
432.433
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Polar area
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158.95
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Complexity
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840.0245467
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xlogp Value
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0.4185
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Heavy Count
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31
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Rot Bonds
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12
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Hbond acc
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7
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Hbond Donor
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3
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
cN112638426B ADC1 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.04 nM
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| Method Description |
A Cell line test on HCC1954
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| In Vitro Model | Breast ductal carcinoma | HCC1954 cells | CVCL_1259 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.43 nM
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| Method Description |
A Cell line test on NCI-N87
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| In Vitro Model | Gastric tubular adenocarcinoma | NCI-N87 cells | CVCL_1603 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.63 nM
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| Method Description |
A Cell line test on BT-474
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| In Vitro Model | Invasive breast carcinoma | BT-474 cells | CVCL_0179 | ||
| Experiment 4 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
194.24 nM
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| Method Description |
A Cell line test on MDA-MB-468
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| In Vitro Model | Breast adenocarcinoma | MDA-MB-468 cells | CVCL_0419 | ||
| Experiment 5 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
204.88 nM
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| Method Description |
A Cell line test on MCF-7
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| In Vitro Model | Invasive breast carcinoma | MCF-7 cells | CVCL_0031 | ||
References