Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)
ADC ID
DRG0MQAEC
ADC Name
isumab01-C6
Synonyms
Isumab01-C6
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Organization
MURGITROYD & COMPANY
Drug Status
Investigative
Drug-to-Antibody Ratio
3.3
Antibody Name
Undisclosed
Antigen Name
Folate receptor alpha (FOLR1)
  Antigen Info 
Payload Name
WO2025015586A1, ADC24, Payload
  Payload Info 
Therapeutic Target
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8)
  Target Info 
Linker Name
Undisclosed
General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Click To Hide/Show 3 Activity Data Related to This Level
Standard Type Value Units Cell Line Disease Model
Half Maximal inhibitory Concentration (lC50) 
0.002
pM
CVCL_0218
Colon adenocarcinoma
Half Maximal inhibitory Concentration (lC50) 
8
pM
CVCL_1530
Lung non-small cell carcinoma
Half Maximal inhibitory Concentration (lC50) 
9
pM
CVCL_0363
Gestational choriocarcinoma
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
Click To Hide/Show 3 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50) 0.002 pM High FRa expression (FRa +++)
Method Description
A Cell line test on Colo205
In Vitro Model Colon adenocarcinoma Colo205 cells CVCL_0218
Experiment 2 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50) 8 pM High FRa expression (FRa +++)
Method Description
A Cell line test on H2110
In Vitro Model Lung non-small cell carcinoma H2110 cells CVCL_1530
Experiment 3 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal inhibitory Concentration (lC50) 9 pM High FRa expression (FRa +++)
Method Description
A Cell line test on Jeg3
In Vitro Model Gestational choriocarcinoma Jeg3 cells CVCL_0363
References
Ref 1 Antibody-drug conjugate compounds, and methods of use and treatment