Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0LNDIM
|
|||||
|---|---|---|---|---|---|---|
| ADC Name |
Hu103-32-2-A (2)
|
|||||
| Synonyms |
Hu103-32-2-A (2)
Click to Show/Hide
|
|||||
| Organization |
JIANGSU HENGRUI MEDICINE CO., LTD.
|
|||||
| Drug Status |
Investigative
|
|||||
| Drug-to-Antibody Ratio |
4.8
|
|||||
| Structure |
|
|||||
| Antibody Name |
Hu103
|
Antibody Info | ||||
| Antigen Name |
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)
|
Antigen Info | ||||
| Payload Name |
RU2833323C1+Hu63-13-2-A+payload
|
Payload Info | ||||
| Linker Name |
Mc-Gly-Gly-Phe-Gly
|
Linker Info | ||||
| Conjugate Type |
Random conjugation through reduced inter-chain cysteines.
|
|||||
General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | 2.863 nM | High CEACAM5 expression (CEACAM5 +++) | ||
| Method Description |
A Cell line test on MKN45
|
||||
| In Vitro Model | Gastric adenocarcinoma | MKN45 cells | CVCL_0434 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | 3.076 nM | Moderate CEACAM5 expression (CEACAM5++) | ||
| Method Description |
A Cell line test on LS174T
|
||||
| In Vitro Model | Colon adenocarcinoma | LS174T cells | CVCL_1384 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | 83.58 nM | Negative CEACAM5 expression (CEACAM5-) | ||
| Method Description |
A Cell line test on HCT116
|
||||
| In Vitro Model | Colon carcinoma | HCT116 cells | CVCL_0291 | ||