Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0LMKYQ
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| ADC Name |
AU2023281032A1 ADC-1
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| Synonyms |
AU2023281032A1 ADC-1
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| Organization |
GENEQUANTUM HEALTHCARE (SUZHOU)CO.,LTD[CN/CN]
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| Drug Status |
Investigative
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| Drug-to-Antibody Ratio |
1.93
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| Structure |
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| Antibody Name |
undisclosed
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Antigen Name |
Undisclosed
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| Payload Name |
Monomethyl auristatin E
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Payload Info | ||||
| Therapeutic Target |
Microtubule (MT)
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Target Info | ||||
| Linker Name |
AU2023281032A1 ADC-1 linker
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Linker Info | ||||
| Conjugate Type |
site-specific conjugation
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| Combination Type |
LP-1
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General Information of The Activity Data Related to This ADC
Discovered Using Cell Line-derived Xenograft Model
| Standard Type | Value | Units | Cell Line | Disease Model |
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| Tumor Growth lnhibition value (TGl) |
115.07
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%
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Undisclosed | Undisclosed |
Revealed Based on the Cell Line Data
Full List of Activity Data of This Antibody-drug Conjugate
Discovered Using Cell Line-derived Xenograft Model
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth lnhibition value (TGl) |
115.07%
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| Method Description |
Inhibition Effect of ADC-1,3mg/kg on NCI-N87 CDX Mouse Model
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| In Vivo Model | NCI-N87 CDX Mouse Model | ||||
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.04636 nM
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| Method Description |
Proliferation Inhibition Effect of Different Drugs on Tumor Cells (IC50, nM)in BT-474,
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| In Vitro Model | Invasive breast carcinoma | BT-474 cells | CVCL_0179 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.08706 nM
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| Method Description |
Proliferation Inhibition Effect of Different Drugs on Tumor Cells (IC50, nM)in NCI-N87
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| In Vitro Model | Gastric tubular adenocarcinoma | NCI-N87 cells | CVCL_1603 | ||
References