Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0LCZYT
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| ADC Name |
CD74 Milatuzumab DANAPAE152C S375C-P1-L35-P1
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| Synonyms |
CD74 Milatuzumab DANAPAE152C S375C-P1-L35-P1
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| Organization |
NOVARTIS AG
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| Drug Status |
Investigative
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| Drug-to-Antibody Ratio |
4
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| Antibody Name |
CD74 Milatuzumab DANAPAE152C S375C
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Antibody Info | ||||
| Antigen Name |
HLA class II histocompatibility antigen gamma chain (CD74)
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Antigen Info | ||||
| Payload Name |
P1 payload
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Payload Info | ||||
| Linker Name |
L35 linker
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Linker Info | ||||
| Conjugate Type |
Random conjugation through reduced inter-chain cysteines
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General Information of The Activity Data Related to This ADC
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | 0.853 nM | High CD74 expression (CD74 +++) | ||
| Method Description |
CD74 Milatuzumab DANAPAE152C S375C-P1-L35-P1 was tested in EOL-1
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| In Vitro Model | Chronic eosinophilic leukemia | EoL-1 cells | CVCL_0258 | ||