Linker Information
General Information of This Linker
| Linker ID |
LIN0JKALY
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| Linker Name |
L35 linker
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| Linker Type |
Cathepsin-cleavable linker
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| Antibody-Linker Relation |
Cleavable
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| Structure |
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| Formula |
C185H331N19O80
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| Isosmiles |
CN(CC1=CC(NC([C@@H](NC([C@@H](NC(OCCN(N=N2)C=C2COCCOCCC(N[C@H](C(NCCOCCOCCC(N[C@@H](C(C)C)C(N[C@H](C(NC3=CC(CN(C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O)=O)C)=C(O)C=C3)=O)CCCNC(N)=O)=O)=O)=O)CCCCNC(CCOCCOCCOCCOCCN4C(C=CC4=O)=O)=O)=O)=O)C(C)C)=O)CCCNC(N)=O)=O)=CC=C1O)C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O)=O
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| InChI |
InChI=1S/C185H331N19O80/c1-155(2)176(181(221)195-163(12-9-28-190-183(186)223)179(219)192-159-14-16-165(205)157(149-159)151-201(5)170(210)23-36-229-45-52-236-58-63-241-67-71-245-75-79-249-83-87-253-91-95-257-99-103-261-107-111-265-115-119-269-123-127-273-131-135-277-139-143-281-145-141-279-137-133-275-129-125-271-121-117-267-113-109-263-105-101-259-97-93-255-89-85-251-81-77-247-73-69-243-65-60-238-54-47-231-38-25-174(214)215)197-169(209)22-35-227-43-49-233-40-30-189-178(218)162(11-7-8-27-188-167(207)20-33-226-44-51-235-57-62-240-56-50-234-41-32-204-172(212)18-19-173(204)213)194-168(208)21-34-228-147-148-283-154-161-153-203(200-199-161)31-42-284-185(225)198-177(156(3)4)182(222)196-164(13-10-29-191-184(187)224)180(220)193-160-15-17-166(206)158(150-160)152-202(6)171(211)24-37-230-46-53-237-59-64-242-68-72-246-76-80-250-84-88-254-92-96-258-100-104-262-108-112-266-116-120-270-124-128-274-132-136-278-140-144-282-146-142-280-138-134-276-130-126-272-122-118-268-114-110-264-106-102-260-98-94-256-90-86-252-82-78-248-74-70-244-66-61-239-55-48-232-39-26-175(216)217/h14-19,149-150,153,155-156,162-164,176-177,205-206H,7-13,20-148,151-152,154H2,1-6H3,(H,188,207)(H,189,218)(H,192,219)(H,193,220)(H,194,208)(H,195,221)(H,196,222)(H,197,209)(H,198,225)(H,214,215)(H,216,217)(H3,186,190,223)(H3,187,191,224)/t162-,163-,164-,176-,177-/m0/s1
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| InChIKey |
AEJWTFUOANGSBG-OFOLTZHESA-N
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| Pharmaceutical Properties |
Molecule Weight
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4101.736
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Polar area
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1140.48
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Complexity
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.
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xlogp Value
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-0.1831
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Heavy Count
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284
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Rot Bonds
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222
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Hbond acc
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81
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Hbond Donor
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17
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Each Antibody-drug Conjugate Related to This Linker
Full Information of The Activity Data of The ADC(s) Related to This Linker
CD74 Milatuzumab DANAPAE152C S375C-P1-L35-P1 [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) |
0.853 nM
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High CD74 expression (CD74 +++) | ||
| Method Description |
CD74 Milatuzumab DANAPAE152C S375C-P1-L35-P1 was tested in EOL-1
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| In Vitro Model | Chronic eosinophilic leukemia | EoL-1 cells | CVCL_0258 | ||