Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0KTMRR
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| ADC Name |
wO2023232144A1ADC-3
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| Synonyms |
WO2023232144A1ADC-3
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| Organization |
GeneQuantum Healthcare (Suzhou) Co. Ltd.
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| Drug Status |
Investigative
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| Drug-to-Antibody Ratio |
3.93
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| Structure |
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| Antibody Name |
anti-TROP2 antibody mAb-2
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Antibody Info | ||||
| Antigen Name |
Tumor-associated calcium signal transducer 2 (TACSTD2)
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Antigen Info | ||||
| Payload Name |
WO2023232144A1, ADC-2, Payload
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Payload Info | ||||
| Therapeutic Target |
DNA topoisomerase I (TOP1)
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Target Info | ||||
| Linker Name |
WO2023232144A1, ADC-2, linker
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Linker Info | ||||
| Combination Type |
LP-6
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General Information of The Activity Data Related to This ADC
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | 0.1839 nM | High TROP2 expression (TROP2 +++) | ||
| Method Description |
Cytotoxicity of ADC to FaDu cells
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| In Vitro Model | Hypopharyngeal squamous cell carcinoma | FaDu cells | CVCL_1218 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | 0.1928 nM | High TROP2 expression (TROP2 +++) | ||
| Method Description |
Cytotoxicity of ADC-2 to BxPC-3 cells
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| In Vitro Model | Pancreatic ductal adenocarcinoma | BxPC-3 cells | CVCL_0186 | ||
References