Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0IPORF
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| ADC Name |
HN-01
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| Synonyms |
HN01; HN 01
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| Drug Status |
Investigative
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| Drug-to-Antibody Ratio |
3.33
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| Antibody Name |
Anti-CD24 G7mAb
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Antibody Info | ||||
| Antigen Name |
Signal transducer CD24 (CD24)
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Antigen Info | ||||
| Payload Name |
Diazeniumdiolate
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Payload Info | ||||
| Linker Name |
Mc-disulfane based linker
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Linker Info | ||||
| Conjugate Type |
Random conjugation through reduced inter-chain cysteines.
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General Information of The Activity Data Related to This ADC
Full List of Activity Data of This Antibody-drug Conjugate
Discovered Using Cell Line-derived Xenograft Model
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 81.30% | Positive CD24 expression (CD24 +++/++) | ||
| Method Description |
A hepatocellular carcinoma xenograft model was established by subcutaneously injecting BEL-7402 cells (1 x 107) into right flanks of BALB/c nude mice. When the average tumor volume reached 100 mm3, tumor-bearing mice were divided randomly into seven groups (six mice/group) and treated with HN-01 (10 mg/kg) every 3 days.
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| In Vivo Model | BEL-7402 CDX model | ||||
| In Vitro Model | Hepatoma | Bel-7402 cells | CVCL_5492 | ||
References